| sess_SDA-2026-04-10- | The abstract claims Cdk5 activation is the primary cause of AD, contradicting th | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-pubmed-20260410-185251-10f6a211 |
| sess_SDA-2026-04-11- | The debate highlighted a fundamental uncertainty about whether transgenerational | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-105844-45a775a2 |
| sess_SDA-2026-04-11- | The debate highlighted focused ultrasound as most feasible but didn't resolve cr | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110223-e27ddf73 |
| sess_SDA-2026-04-11- | The debate assumed that correcting APOE4's aberrant domain interactions would re | 0.43 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110241-04eef441 |
| sess_SDA-2026-04-11- | The debate highlighted that speech timing and sleep changes could reflect circad | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110253-5fa88b6d |
| sess_SDA-2026-04-11- | Multiple participants noted the conflation of cellular dysfunction with senescen | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110715-ae1eeb19 |
| sess_SDA-2026-04-11- | The debate highlighted that while SCFAs can cross the blood-brain barrier, the a | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110745-72201cc8 |
| sess_SDA-2026-04-11- | The debate identified systemic toxicity as a major concern for glucosylceramide | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111106-df334a52 |
| sess_SDA-2026-04-11- | The debate highlighted that RNA granules serve essential physiological functions | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111130-9967ed0e |
| sess_SDA-2026-04-11- | The debate revealed a fundamental gap: whether disease-specific C1q conformation | 0.51 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111529-85a3197f |
| sess_SDA-2026-04-11- | The debate highlighted that mitochondrial transfer could be therapeutic, but rai | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111536-ebde9783 |
| sess_SDA-2026-04-11- | The stage-dependent strategy assumes sequential drug switching is feasible, but | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111928-22fc607c |
| sess_SDA-2026-04-11- | The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111936-47b73d88 |
| sess_SDA-2026-04-11- | All participants agreed that transcriptomic vulnerability signatures don't estab | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111936-9a9b8c46 |
| sess_SDA-2026-04-11- | The debate revealed a critical gap: while excitatory neurons show mitochondrial | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111943-688d4ed6 |
| sess_SDA-2026-04-10- | While genetic evidence links autophagy dysfunction to neurodegeneration, the deb | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-113045-6fcb3f6c |
| sess_SDA-2026-04-10- | The core causation versus correlation debate remains unresolved despite being ce | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-112348-a10cb6b4 |
| sess_SDA-2026-04-10- | All participants identified BBB penetration as a critical bottleneck, but no exi | 0.50 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-112625-6c2ceffa |
| sess_SDA-2026-04-19- | Investigate shared DNA methylation age acceleration and histone modification pat | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| sess_SDA-2026-04-11- | The debate generated therapeutic hypotheses targeting different cell types but n | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112336-ccdef571 |
| sess_SDA-2026-04-11- | The debate identified that ketone levels >2.0 mM may disrupt astrocyte-neuron me | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112343-6340ce52 |
| sess_SDA-2026-04-11- | The debate proposed temporal TFEB modulation but identified no validated biomark | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112348-d9e9b948 |
| sess_SDA-2026-04-11- | The debate highlighted major safety concerns about blocking CXCL10, particularly | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112406-461e1f01 |
| sess_SDA-2026-04-11- | The debate raised conflicting views on whether myelin restoration would be benef | 1.00 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-112430-676f2b59 |
| sess_SDA-2026-04-11- | The debate highlighted P2RX7's dual role in both harmful exosome secretion and b | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-112451-1ee4bcc4 |
| sess_SDA-2026-04-11- | The debate highlighted fundamental disagreement about tau's role - whether aggre | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-112457-6c066349 |
| sess_SDA-2026-04-11- | The debate revealed conflicting therapeutic approaches - enhancing DNA repair ve | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-112503-d3625e8c |
| sess_SDA-2026-04-18- | Investigate shared DNA methylation age acceleration and histone modification pat | 1.00 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-18-gap-epigenetic-comparative-ad-pd-als |
| sess_SDA-2026-04-16- | Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma | 0.50 | 7 | 4 | completed | 2026-04-20 | SDA-2026-04-16-gap-20260416-220243 |
| sess_SDA-2026-04-02- | What are the mechanisms by which tau pathology spreads through connected brain r | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-02-gap-tau-propagation-20260402 |
| wrap_SDA-2026-04-17- | The fundamental premise remains unvalidated despite extensive mechanistic specul | 1.00 | 7 | 4 | completed | 2026-04-19 | SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2 |
| sess_SDA-2026-04-16- | How does lncRNA-0021 achieve sequence-specific binding to mmu-miR-6361 and what | 0.50 | 3 | 4 | completed | 2026-04-18 | |
| sess_SDA-2026-04-11- | The debate proposed P16INK4A-guided targeting but the Skeptic noted microglia ex | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112619-9c3c13d2 |
| sess_SDA-2026-04-11- | The debate highlighted that long-term CRISPR expression triggers immune response | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112625-c44578b5 |
| sess_SDA-2026-04-11- | The debate highlighted that TREM2 therapeutic targeting remains contested across | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112636-141592ba |
| sess_SDA-2026-04-11- | The debate transcript shows incomplete analysis where the Theorist reached maxim | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112649-f72c1ba2 |
| sess_SDA-2026-04-11- | The debate aimed to cross-reference Allen Aging Mouse Brain Atlas data with huma | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112700-e284319e |
| sess_SDA-2026-04-11- | The debate was initiated to analyze cell-type-specific vulnerability using SEA-A | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112706-7f5a9480 |
| sess_SDA-2026-04-11- | The debate initiated investigation into white matter aging and myelin changes bu | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112718-0b78e493 |
| sess_SDA-2026-04-11- | The debate failed to produce any actual hypotheses despite this being the core r | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-11-gap-debate-20260410-112725-4369698d |
| sess_SDA-2026-04-12- | The debate was structured to identify aging-neurodegeneration mechanisms using A | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-12-gap-debate-20260410-112741-51d89235 |
| sess_SDA-2026-04-12- | The debate transcript shows incomplete information exchange, suggesting this fun | 0.49 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-12-gap-debate-20260410-112747-72269a36 |
| sess_SDA-2026-04-12- | The debate highlighted the bidirectional relationship between sleep and neurodeg | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-12-gap-debate-20260410-112754-fc3e63c8 |
| sess_SDA-2026-04-12- | The theorist proposed this novel approach to enable safe agonism across disease | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-12-gap-debate-20260410-112812-429571d2 |
| sess_SDA-2026-04-12- | The debate revealed that no high-resolution structure exists for the critical hi | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-12-gap-debate-20260410-112837-d8c6fc48 |
| sess_SDA-2026-04-12- | The debate proposed bioenergetic gradients drive transfer but didn't identify th | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-12-gap-debate-20260410-112842-e2dec0d7 |
| sess_SDA-2026-04-16- | How does synaptic protein turnover change with age and neurodegeneration, and wh | 0.50 | 7 | 4 | completed | 2026-04-18 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| sess_SDA-2026-04-16- | What are the key metabolic alterations detectable in brain tissue, CSF, and bloo | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| sess_SDA-2026-04-16- | How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pa | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| sess_SDA-2026-04-16- | How does chronic peripheral inflammation interact with CNS neuroimmune pathways | 0.50 | 0 | 4 | completed | 2026-04-18 | SDA-2026-04-16-frontier-immunomics-e6f97b29 |