| target_debate_target | Should TREM2 (Triggering receptor expressed on myeloid cells 2) be prioritized a | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should PDGFRB (Platelet-derived growth factor receptor beta) be prioritized as a | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) be priorit | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should GLP1R (Glucagon-like peptide-1 receptor) be prioritized as a therapeutic | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should G3BP1 (Ras GTPase-activating protein-binding protein 1) be prioritized as | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should NLRP3 (NACHT, LRR and PYD domains-containing protein 3) be prioritized as | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The study shows P2RY12 regulates VSMC foam cell formation but doesn't explain wh | 0.66 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a |
| target_debate_target | Should MTNR1B (Melatonin receptor 1B) be prioritized as a therapeutic target for | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The abstract describes IBA1 low/negative microglia in individuals with liver dis | 0.76 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| target_debate_target | Should P2RY1 (P2Y purinoreceptor 1) be prioritized as a therapeutic target for n | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The abstract states that AQP4 'is part of the pathogenesis' of CNS disorders and | 0.76 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| target_debate_target | Should IL1B (Interleukin-1 beta) be prioritized as a therapeutic target for neur | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The debate raised this developmental hypothesis but couldn't resolve the mechani | 0.71 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |
| target_debate_target | Should TH (Tyrosine hydroxylase) be prioritized as a therapeutic target for neur | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The debate considered multiple propagation routes (synaptic, extracellular vesic | 0.66 | 6 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062052-946439a8 |
| target_debate_target | Should PARP1 (Poly [ADP-ribose] polymerase 1) be prioritized as a therapeutic ta | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should C3 (Complement C3) be prioritized as a therapeutic target for neurodegene | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The sequential therapy hypothesis depends on identifying when autophagy failure | 0.78 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| target_debate_target | Should KCNK2 (Potassium two pore domain channel subfamily K member 2) be priorit | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms | 0.71 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| target_debate_target | Should PRKAA1 (AMP-activated protein kinase catalytic subunit alpha-1) be priori | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should RAB7A (Ras-related protein Rab-7a) be prioritized as a therapeutic target | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The study shows C1qa tags synapses for microglial elimination, but doesn't expla | 0.75 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |
| target_debate_target | Should MTNR1A (Melatonin receptor 1A) be prioritized as a therapeutic target for | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should BCL2L1 (BCL2 Like 1) be prioritized as a therapeutic target for neurodege | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The abstract mentions multiple organelles synchronously present structural deran | 0.80 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| target_debate_target | Should P2RX7 (P2X purinoreceptor 7) be prioritized as a therapeutic target for n | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m | 0.73 | 6 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| target_debate_target | Should IDH2 (Isocitrate Dehydrogenase 2) be prioritized as a therapeutic target | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should DRD2 (Dopamine receptor D2) be prioritized as a therapeutic target for ne | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should CACNA1G (Voltage-dependent T-type calcium channel subunit alpha-1G) be pr | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should LDLR (Low density lipoprotein receptor) be prioritized as a therapeutic t | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| target_debate_target | Should GABRA1 (Gamma-aminobutyric acid receptor subunit alpha-1) be prioritized | 0.50 | 0 | 4 | completed | 2026-04-21 | |
| sess_SDA-2026-04-07- | While the study establishes that trehalose-induced lysosomal permeabilization ac | 0.73 | 4 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba |
| sess_SDA-2026-04-07- | TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi | 0.70 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-094b44bf |
| sess_SDA-2026-04-07- | The abstract mentions that pathological seeds have different characteristics and | 0.65 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062207-e4ce5cf0 |
| sess_SDA-2026-04-07- | The abstract identifies that neurons show resistance to autophagy induction, but | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c |
| sess_SDA-2026-04-08- | SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout | 0.69 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3 |
| sess_SDA-2026-04-08- | While the study demonstrates both NF-κB pathway activation and increased C1qa ex | 0.74 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| sess_SDA-2026-04-08- | While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo | 0.77 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062141-739c7f1c |
| sess_SDA-2026-04-08- | The finding that trehalase-resistant analogs and other disaccharides mimic treha | 0.60 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062150-5b7d1556 |
| sess_SDA-2026-04-08- | The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| sess_SDA-2026-04-08- | Both theorist and domain expert acknowledged that existing epigenetic modulators | 0.72 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| sess_SDA-2026-04-08- | AD patients with TDP-43 pathology show worse cognitive impairment, but how TDP-4 | 0.73 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062202-5c32c50a |
| sess_SDA-2026-04-08- | While ALS-causing mutations impair autophagy factors, the neuron-specific effect | 0.81 | 4 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062212-6777e5dd |
| sess_SDA-2026-04-10- | Investigate mechanisms of epigenetic reprogramming in aging neurons, including D | 0.50 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-20260410-091440 |
| sess_SDA-2026-04-08- | The abstract mentions that antibody discovery has improved understanding of myel | 0.66 | 2 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062111-e3e328bf |
| sess_SDA-2026-04-08- | The review covers various organelle-specific autophagy types but doesn't address | 0.66 | 2 | 4 | completed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062132-5d93ddb2 |
| sess_SDA-2026-04-10- | The clinical trialist identified this as a 'fatal clinical flaw' - no validated | 0.65 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| sess_SDA-2026-04-10- | The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved struc | 0.69 | 5 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075007-232fbf62 |