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Debates

880 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
target_debate_targetShould CASP1 (Caspase-1) be prioritized as a therapeutic target for neurodegener0.5004completed2026-04-21
target_debate_targetShould MMP2 (Matrix metalloproteinase-2) be prioritized as a therapeutic target 0.5004completed2026-04-21
target_debate_targetShould HCN1 (Hyperpolarization-activated cyclic nucleotide-gated potassium chann0.5004completed2026-04-21
target_debate_targetShould PRMT1 (Protein arginine methyltransferase 1) be prioritized as a therapeu0.5004completed2026-04-21
target_debate_targetShould SOAT1 (Sterol O-acyltransferase 1) be prioritized as a therapeutic target0.5004completed2026-04-21
target_debate_targetShould MIRO1 (Mitochondrial Rho GTPase 1) be prioritized as a therapeutic target0.5004completed2026-04-21
target_debate_targetShould TFAM (Transcription factor A, mitochondrial) be prioritized as a therapeu0.5004completed2026-04-21
target_debate_targetShould TNFA (Tumor necrosis factor alpha) be prioritized as a therapeutic target0.5004completed2026-04-21
target_debate_targetShould GJA1 (Gap junction alpha-1 protein (Connexin 43)) be prioritized as a the0.5004completed2026-04-21
target_debate_targetShould FOXO1 (Forkhead box protein O1) be prioritized as a therapeutic target fo0.5004completed2026-04-21
target_debate_targetShould TFRC (Transferrin receptor protein 1) be prioritized as a therapeutic tar0.5004completed2026-04-21
target_debate_targetShould TLR4 (Toll-like receptor 4) be prioritized as a therapeutic target for ne0.5004completed2026-04-21
target_debate_targetShould STX17 (Syntaxin-17) be prioritized as a therapeutic target for neurodegen0.5004completed2026-04-21
target_debate_targetShould TUBB3 (Tubulin beta-3 chain) be prioritized as a therapeutic target for n0.5004completed2026-04-21
target_debate_targetShould TET2 (Tet methylcytosine dioxygenase 2) be prioritized as a therapeutic t0.5004completed2026-04-21
sess_SDA-2026-04-07-The study shows trehalose causes lysosomal membrane permeabilization (LMP) that 0.6174completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467
target_debate_targetShould NR3C1 (Glucocorticoid receptor) be prioritized as a therapeutic target fo0.5004completed2026-04-21
target_debate_targetShould MMP9 (Matrix metalloproteinase-9) be prioritized as a therapeutic target 0.5004completed2026-04-21
sess_SDA-2026-04-07-While SPP1 absence prevents synaptic loss, it's unclear whether this represents 0.6974completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd
target_debate_targetShould FKBP5 (FKBP prolyl isomerase 5) be prioritized as a therapeutic target fo0.5004completed2026-04-21
sess_SDA-2026-04-07-The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecu0.7974completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c
target_debate_targetShould BDNF (Brain Derived Neurotrophic Factor) be prioritized as a therapeutic 0.5004completed2026-04-21
target_debate_targetShould C1Q (Complement C1q) be prioritized as a therapeutic target for neurodege0.5004completed2026-04-21
sess_SDA-2026-04-07-While the study establishes P2RY12's role in VSMC foam cell formation in atheros0.6274completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041434-d7920f3b
target_debate_targetShould CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1) be prioritized a0.5004completed2026-04-21
target_debate_targetShould TFR1 (Transferrin receptor protein 1) be prioritized as a therapeutic tar0.5004completed2026-04-21
target_debate_targetShould TGM2 (Protein-glutamine gamma-glutamyltransferase 2) be prioritized as a 0.5004completed2026-04-21
sess_SDA-2026-04-07-While the abstract identifies AQP4 as a 'potential and promising target' and men0.7674completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2
target_debate_targetShould SIRT6 (Sirtuin-6) be prioritized as a therapeutic target for neurodegener0.5004completed2026-04-21
target_debate_targetShould CX3CR1 (C-X3-C Motif Chemokine Receptor 1) be prioritized as a therapeuti0.5004completed2026-04-21
sess_SDA-2026-04-07-The circadian hypothesis assumes metabolic switching drives microglial priming, 0.6674completed2026-04-21SDA-2026-04-07-gap-debate-20260406-062033-839c3e2a
target_debate_targetShould LOX (Lysyl oxidase) be prioritized as a therapeutic target for neurodegen0.5004completed2026-04-21
sess_SDA-2026-04-07-The debate identified temporal specificity as a critical weakness - when exactly0.6874completed2026-04-21SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b
target_debate_targetShould P2RY12 (P2Y purinoreceptor 12) be prioritized as a therapeutic target for0.5004completed2026-04-21
target_debate_targetShould HCRTR2 (Hypocretin Receptor 2) be prioritized as a therapeutic target for0.5004completed2026-04-21
sess_SDA-2026-04-07-While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c0.7374completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046
target_debate_targetShould FCGRT (Fc fragment of IgG receptor and transporter) be prioritized as a t0.5004completed2026-04-21
target_debate_targetShould HCRTR1 (Hypocretin Receptor 1) be prioritized as a therapeutic target for0.5004completed2026-04-21
sess_SDA-2026-04-07-The abstract identifies APOE4 association with increased TDP-43 pathology but th0.6174completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062202-c8c5a9a1
target_debate_targetShould SNCA (Synuclein alpha) be prioritized as a therapeutic target for neurode0.5004completed2026-04-21
sess_SDA-2026-04-07-While the study identifies G3BP1 as a central node triggering phase separation, 0.7674completed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741
target_debate_targetShould ULK1 (Unc-51 like autophagy activating kinase 1) be prioritized as a ther0.5004completed2026-04-21
target_debate_targetShould ADRA2A (Alpha-2A adrenergic receptor) be prioritized as a therapeutic tar0.5004completed2026-04-21
target_debate_targetShould HSPA1A (Heat Shock Protein Family A Member 1A) be prioritized as a therap0.5004completed2026-04-21
target_debate_targetShould SLC7A11 (Cystine/glutamate transporter) be prioritized as a therapeutic t0.5004completed2026-04-21
target_debate_targetShould ADORA2A (Adenosine A2A receptor) be prioritized as a therapeutic target f0.5004completed2026-04-21
target_debate_targetShould APOE (Apolipoprotein E) be prioritized as a therapeutic target for neurod0.5004completed2026-04-21
target_debate_targetShould CGAS (Cyclic GMP-AMP synthase) be prioritized as a therapeutic target for0.5004completed2026-04-21
target_debate_targetShould TREM2 (Triggering receptor expressed on myeloid cells 2) be prioritized a0.5004completed2026-04-21
target_debate_targetShould PDGFRB (Platelet-derived growth factor receptor beta) be prioritized as a0.5004completed2026-04-21
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