Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: Concordance between different MRI phenotyping methods
This study assessed the concordance between four different MRI phenotyping methods for Alzheimer's disease in a Serbian cohort of 40 subjects. The four MRI phenotyping approaches compared were: scale-based, adjusted scale-based, volume-based, and thickness-based methods. The study aimed to determine how well these different phenotyping approaches agree with each other in identifying the four predominant MRI phenotypes of AD: typical, hippocampal-sparing, limbic-predominant, and minimal-atrophy. The research also examined relationships with demographic variables and clinical dementia rating (CDR) domains to understand clinical heterogeneity among phenotypes. The findings showed that scale-based methods had moderate agreement with adjusted scale-based approaches and high concordance with volumetric methods, while the relationship with thickness-based phenotyping was less clear.
Four MRI phenotyping approaches were employed (scale-based, adjusted scale-based, volume-based, and thickness-based) to classify AD patients into four phenotypes (typical, hippocampal-sparing, limbic-predominant, and minimal-atrophy). Agreement between methods was assessed along with relationships to demographic variables and clinical dementia rating domains.
The study expected to determine which MRI phenotyping methods show good concordance and could be used interchangeably in clinical settings, particularly identifying practical approaches for resource-limited settings.
Significant concordance between MRI phenotyping methods, particularly validation of scale-based methods as practical alternatives to more advanced techniques
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