Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about THERAPEUTIC TARGET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | THERAPEUTIC TARGET |
graph TD
THERAPEUTIC_TARGET[THERAPEUTIC TARGET]
HSPA1A[HSPA1A] -->|targets| THERAPEUTIC_TARGET
Hdac_Inhibitor[Hdac Inhibitor] -->|targets| THERAPEUTIC_TARGET
MTOR[MTOR] -.biomarker for.-> THERAPEUTIC_TARGET
GSPT1[GSPT1] -.biomarker for.-> THERAPEUTIC_TARGET
TREM2[TREM2] -->|targets| THERAPEUTIC_TARGET
XPR1[XPR1] -->|target for| THERAPEUTIC_TARGET
ALOX15[ALOX15] -->|target for| THERAPEUTIC_TARGET
PARP14[PARP14] -->|target for| THERAPEUTIC_TARGET
senescent_cells[senescent cells] -->|target for| THERAPEUTIC_TARGET
SNCA_fibril_polymorphs[SNCA fibril polymorphs] -->|target for| THERAPEUTIC_TARGET| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Hdac Inhibitor | targets | drug | 0.90 |
| 30334567 | renders Akt a valuable | paper | 0.90 |
| HSPA1A | targets | gene | 0.90 |
| GSPT1 | biomarker_for | gene | 0.88 |
| MTOR | biomarker_for | gene | 0.88 |
| TREM2 | targets | protein | 0.86 |
| XPR1 | therapeutic_target | gene | 0.85 |
| NTN1 | associated_with | protein | 0.85 |
| ALOX15 | therapeutic_target | gene | 0.82 |
| PARP14 | therapeutic_target | gene | 0.80 |
| SNCA fibril polymorphs | therapeutic_target | protein | 0.75 |
| senescent cells | therapeutic_target | cell_type | 0.75 |
| LOXL1 | targets | gene | 0.75 |
| APOE | associated_with | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TDP-43 condensation thermodynamics as a therapeutic target a | 0.710 | neuroscience | How can subcellular compartmentalization |
| CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic T | 0.648 | neurodegeneration | Does clusterin exacerbate or protect aga |
| LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target | 0.594 | neurodegeneration | Gut-Brain Axis in Parkinson's Disease: M |
| Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta | 0.560 | neuroinflammation | How does chronic cGAS/STING activation d |
| MAP6-mediated microtubule stabilization as therapeutic targe | 0.500 | neurodegeneration | View |
| AQP4 Water Channel Normalization as Surrogate Marker and The | 0.105 | neurodegeneration | Neuroinflammation Biomarker Panel for Ea |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692] | Khan JZ, Zainab SR, Alattar A | Neurochem Res | 2025 | 0 |
| Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025] | Unknown | Journal of ethnopharmacology | 2024 | 0 |
| Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915] | Sun W, Wang Q, Zhang R, Zhang N | Food & function | 2023 | 0 |
| NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264] | Ibrahim Weam W; Skalicka-Woźniak K | International immunopharmacolo | 2023 | 0 |
| Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061] | Choi I, Zhang Y, Seegobin SP | Nat Commun | 2020 | 0 |
| Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362] | Mondal A, Bose D, Saha P | J Neuroinflammation | 2020 | 0 |
| RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890] | ["Muhammad T", "Ikram M", "Ullah R", "Re | Nutrients | 2019 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning THERAPEUTIC TARGET in their description or question text