Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synaptic damage: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Copper | associated_with | compound | 0.95 |
| NRF2 | prevents | gene | 0.91 |
| Damaged Mitochondria | causes | process | 0.90 |
| Impaired Mitophagy | causes | process | 0.90 |
| Copper-Trim25-Nfkb-Bnip3 Axis | contributes_to | pathway | 0.90 |
| ISG15 | mediates | gene | 0.90 |
| Suanzaoren Decoction | associated_with | drug | 0.90 |
| DMSA | treats | drug | 0.85 |
| MAPT | causes | gene | 0.70 |
| EAAT2 downregulation | causes | phenotype | 0.70 |
| BNIP3 | regulates | gene | 0.70 |
| C1q inhibition | prevents | therapeutic_target | 0.70 |
| C3 inhibition | prevents | therapeutic_target | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.822
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
Hypotheses and analyses mentioning synaptic damage in their description or question text
No additional research found