Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C3 inhibition: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurotoxic synapse elimination | prevents | mechanism | 0.70 |
| synapse elimination | prevents | mechanism | 0.70 |
| synaptic damage | prevents | phenotype | 0.70 |
| complement-mediated synapse elimination | inhibits | mechanism | 0.70 |
| complement-mediated synapse elimination | prevents | mechanism | 0.70 |
| SYNAPSE_ELIMINATION | inhibits | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Selective HDAC3 Inhibition with Cognitive Enhancement | 0.779 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Complement C1q/C3 Inhibition to Prevent Synaptodendritis in | 0.690 | neurodegeneration | Test |
Scientific analyses that reference this entity
research methodology | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.782
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Mechanism: Why Does Amyloid Removal Only Slow Decline 27%? | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Animal Model Comparison for Neurodegenerative Disease Therapeutics | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Epigenetic Dysregulation in Huntington's Disease — Therapeutic Targeti | validation | Neurodegeneration | 0.400 | 0.50 | human | completed | $3,000,000 |
| Epigenetic Dysregulation Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Discovery of a Covalent HDAC3 Degrader with Excellent Anti-Inflammatory Activity [PMID:41812251] | ["Qin H", "Shi Y", "Liu R", "Wang B", "G | Journal of medicinal chemistry | 2026 | 0 |
| Myeloid HDAC3 deletion protects against traumatic optic injury. [PMID:41851071] | Shahror RA, Morris CA, Cunningham A, Chu | Cell death discovery | 2026 | 0 |
| HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis [PMID:41023273] | Mitchell CD, Morris CA, Wild M, Cunningh | Acta Pharmacol Sin | 2026 | 0 |
| Metabolomics identifies riboflavin as a therapeutic agent for acute pancreatitis [PMID:41352543] | Shi Y, Peng J | J Nutr Biochem | 2026 | 0 |
| β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral ed [PMID:41535708] | Yu MJ, Xiong RQ, Wu JW, Li YC, Xie JX et | Acta Pharmacol Sin | 2026 | 0 |
| SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibi [PMID:41736683] | Wen T, Yang L, Cai S, Liu Y, Fan J et al | Adv Sci (Weinh) | 2026 | 0 |
| Histone deacetylases: Function in tumor development and therapeutic prospects (R [PMID:41783166] | Lin R, Zhang Y, Li H, Liang F | Oncol Lett | 2026 | 0 |
| LncRNA SNHG5 promotes macrophage lipid accumulation and aggravates atheroscleros [PMID:41844502] | Liu X, Wang HH, Lan XY, Sun SY, Xu XD, H | Biochimica et biophysica acta. | 2026 | 0 |
| HOX code-based stratification reveals RUNX1T1-HDAC reprogramming as a targetable [PMID:41912135] | Jiang Y, Cheng S, Zhang CY, Jin X, Li L, | Cancer letters | 2026 | 0 |
| Microglial HDAC3 inhibits the migration of CD8-positive T cell in the developmen [PMID:41888851] | Na Che; Yang Zhang; Bo Wang; Hongxing Wu | Cell & bioscience | 2026 | 0 |
| GR/HDAC3 Regulates Npas4 Signaling Pathway and Mediates Cognitive Impairment in [PMID:41837847] | Zhao Z, Song Y, Yu X, Gao Q, Wang B, Sun | FASEB journal : official publi | 2026 | 0 |
| EXPRESS: Identification of Acetylation-Related Molecular Signatures in Knee Oste [PMID:41876476] | Wang J, Xu B, Yoon DE, Xu S, Xia S, Xu J | Molecular pain | 2026 | 0 |
| The Mechanism of GABA in Attenuating Neuroinflammation in Alzheimer's Disease: C [PMID:41829110] | ["Zhang J", "Wu S", "Meng N", "Li C", "Z | Foods (Basel, Switzerland) | 2026 | 0 |
| NKAPL facilitates transcription pause-release and bridges elongation to initiati [PMID:39824811] | ["Kang Z", "Xu C", "Lu S", "Gong J", "Ya | Nature communications | 2025 | 0 |
| Epigenetic therapy meets targeted protein degradation: HDAC-PROTACs in cancer tr [PMID:40667573] | ["Hussain M", "Zhang L", "Rana A", "Maqb | Future medicinal chemistry | 2025 | 0 |
| Epigenetic Modulation and Neuroprotective Effects of Neurofabine-C in a Transgen [PMID:41153431] | ["Carrera I", "Naidoo V", "Corzo L", "Ma | Genes | 2025 | 0 |
| Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury [PMID:40485011] | ["Xu T", "Ye L", "Li W", "Liu F", "Wei T | CNS neuroscience & therapeutic | 2025 | 0 |
| PROTAC-Based HDAC Degradation: A Paradigm Shift in Targeted Epigenetic Therapies [PMID:41160773] | Himaja A, Halder D, Banerjee S, Biswas S | ChemMedChem | 2025 | 0 |
| Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HD [PMID:37721401] | Hu Y, Lv Y, Long X, Yang G, Zhou J | CNS neuroscience & therapeutic | 2024 | 0 |
| Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate c [PMID:38711064] | ["Yang Q", "Zhang M", "Yang L", "Wang J" | Arthritis research & therapy | 2024 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-02
Hypotheses and analyses mentioning C3 inhibition in their description or question text
No additional research found