protein

SFPQ-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SFPQ-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

SFPQ Protein

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🔬 Protein Info

Gene Symbol	SFPQ
Full Name	PROTEIN
Chromosome	1p35.3
Protein Type	RNA-binding protein, Splicing factor
Function	encodes a nuclear RNA-binding protein that functions as a critical regulator of alternative splicing, transcriptional regulation, and RNA processing.
Molecular Weight	76 kDa
Amino Acids	664 aa
Pathways	Alpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt ID	[P23246](https://www.uniprot.org/uniprot/P23246)
Ensembl ID	ENSG00000116560
OMIM	605199
GeneCards	SFPQ
Human Protein Atlas	SFPQ
Associated Diseases	Als, Alzheimer, Parkinson
Interactions	ALZHEIMER, APOE, APP, CALB1, CCNF, CCT4
KG Connections	124 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SFPQ-PROTEIN — AlphaFold P23246 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    A["Gene expression"] --> B["SFPQ PROTEIN"]
    B --> C["Protein folding and
quality control"]
    B --> D["Cellular signaling"]
    C --> E["Proteostasis"]
    D --> F["Neurotoxicity"]
    E --> G["Disease outcome"]
    F --> G
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class B protein
    class G disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SFPQ-PROTEIN in their description or question text

No additional research found