Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about manganese: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| ROS | activates | process | 0.95 |
| PINK1/Parkin-mediated mitophagy | inhibits | process | 0.95 |
| Parkinson's disease | causes | disease | 0.92 |
| Nf-Κb Signaling | activates | pathway | 0.90 |
| APOPTOSIS | associated_with | process | 0.85 |
| ASTROCYTES | causes | cell_type | 0.85 |
| Glutamate Homeostasis | associated_with | process | 0.85 |
| PARKINSON'S DISEASE | causes | disease | 0.85 |
| hepatic encephalopathy | causes | disease | 0.70 |
| basal ganglia | associated_with | brain_region | 0.70 |
| Hepatic Encephalopathy | contributes_to | disease | 0.70 |
| SLC1A2 | inhibits | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| WNT | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Dow | 0.517 | neuroinflammation | What causes IBA1 low/negative microglia |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning manganese in their description or question text
No additional research found