gene

HCRT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCRT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

15Outgoing

6Incoming

0Experiments

0Debates

Summary

HCRTR1

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🧬 Gene Info

Gene Symbol	HCRT1
Full Name	HCRTR1
Protein Type	Gene
Function	The HCRT1 (Hypocretin/Orexin 1) gene encodes the orexin-A neuropeptide, a critical regulator of arousal, wakefulness, and energy homeostasis
Amino Acids	33 aa
Pathways	Sleep-Wake Regulation
GeneCards	HCRT1
Human Protein Atlas	HCRT1
Associated Diseases	Als, Narcolepsy, Sleep Disorder
Interactions	OXR1
KG Connections	21 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    HCRT1["HCRT1"]
    HCRT1 -->|"expressed in"| Neuron["Neuron"]
    HCRT1 -->|"activates"| HCRT["HCRT"]
    HCRT1 ---|"associated"| ALS["ALS"]
    HCRT1 ---|"associated"| Sleep_Disorder["Sleep Disorder"]
    HCRT1 ---|"associated"| Als["Als"]
    HCRT1 ---|"associated"| App["App"]
    narcolepsy["narcolepsy"] -->|"activates"| HCRT1
    OXR1["OXR1"] -->|"inhibits"| HCRT1
    AND["AND"] ---|"associated"| HCRT1
    HCRTR2["HCRTR2"] ---|"associated"| HCRT1
    HCRTR1["HCRTR1"] ---|"associated"| HCRT1

Outgoing (15)

Target	Relation	Type	Str
Narcolepsy	causes	disease	0.90
Sleep-Wake Regulation	involved_in	process	0.85
ALS	associated_with	disease	0.65
Sleep Disorder	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuron	associated_with	cell_type	0.60
HCRT2	associated_with	gene	0.60
HCRTR1	associated_with	gene	0.60
HCRTR2	associated_with	gene	0.60
App	associated_with	protein	0.60
Neuron	expressed_in	cell_type	0.55
HCRT	associated_with	concept	0.50
CEREBROSPINAL FLUID	associated_with	concept	0.50
HCRT	activates	concept	0.50
HCRT	inhibits	concept	0.50

Incoming (6)

Source	Relation	Type	Str
AND	associated_with	gene	0.60
HCRTR1	associated_with	gene	0.50
OXR1	associated_with	protein	0.50
narcolepsy	activates	disease	0.50
OXR1	inhibits	protein	0.50
HCRTR2	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HCRT1 in their description or question text

No additional research found