protein

GALECTIN-3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GALECTIN-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

3Hypotheses

2Analyses

21Outgoing

11Incoming

0Experiments

2Debates

Summary

Galectin-3 (LGALS3) is a beta-galactosidase-binding lectin expressed in microglia, astrocytes, and neurons, playing critical roles in neuroinflammation, phagocytosis, and neurodegeneration in Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

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🔬 Protein Info

Gene Symbol	GALECTIN
Aliases	LGALS3
Chromosome	14q22.3
Protein Type	Protein
Molecular Weight	29.7 kDa
Amino Acids	250 aa
Exons	6
Pathways	Huntington's disease pathogenesis
UniProt ID	Search UniProt
GeneCards	GALECTIN
Human Protein Atlas	GALECTIN
C-terminal tail	Critical for lectin activity and multimerization
Microglia	Low baseline expression, dramatically upregulated in disease states
Astrocytes	Moderate expression in reactive astrocytes
Neurons	Minimal expression under normal conditions
Associated Diseases	Alzheimer's disease
Known Drugs/Compounds	Berbamine hydrochloride
Interactions	ALZHEIMER, CLEC7A, TREM2
KG Connections	11 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GALECTIN-3 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Galectin-3 Protein

protein · 1227 words

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Pathway Diagram

graph TD
    GALECTIN_3(["GALECTIN-3"])
    TREM2(["TREM2"])
    Alzheimer_s_disease["Alzheimer's disease"]
    CLEC7A["CLEC7A"]
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER_S["ALZHEIMER'S"]
    microglia["microglia"]

    GALECTIN_3 -->|"interacts with"| TREM2
    GALECTIN_3 -->|"implicated in"| Alzheimer_s_disease
    GALECTIN_3 -->|"activates"| CLEC7A
    GALECTIN_3 -->|"activates"| ALZHEIMER
    GALECTIN_3 -->|"activates"| ALZHEIMER_S
    microglia -->|"activates"| GALECTIN_3

    style GALECTIN_3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style TREM2 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style Alzheimer_s_disease fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style CLEC7A fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style ALZHEIMER fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style ALZHEIMER_S fill:#1a1a2e,stroke:#ffd54f,stroke-width:2px,color:#fff
    style microglia fill:#1a2a3a,stroke:#ffa726,stroke-width:2px,color:#fff

Outgoing (21)

Target	Relation	Type	Str
NLRP3	activates	protein	0.90
TREM2	binds_to	protein	0.90
Neuroinflammation	mediates	process	0.90
Th17 cell differentiation	promotes	process	0.87
immunosuppression	promotes	process	0.85
Huntington's disease pathogenesis	involved_in	mechanism	0.85
lysophagy	biomarker_for	process	0.85
neutrophil infiltration	promotes	process	0.84
Alzheimer's disease	implicated_in	disease	0.80
TREM2	interacts_with	protein	0.80
CD47	associated_with	protein	0.80
Aβ plaques	colocalizes_with	phenotype	0.70
lysosomal damage sensing	regulates	mechanism	0.70
microglial activation	promotes	mechanism	0.70
Aβ phagocytosis	enhances	mechanism	0.70
NLRP3 inflammasome assembly	modulates	mechanism	0.70
autophagosomal_degradation	enhances	process	0.70
tau_vesicle_clearance	enhances	mechanism	0.50
ALZHEIMER	activates	gene	0.50
ALZHEIMER'S	activates	concept	0.50
CLEC7A	activates	gene	0.50

Incoming (11)

Source	Relation	Type	Str
Berbamine hydrochloride	inhibits	compound	0.95
31375685	contributed to inflammation through	paper	0.90
37208177	accumulated in	paper	0.90
37208177	increases	paper	0.90
37208177	was elevated in	paper	0.90
37208177	exacerbated	paper	0.90
tetrandrine	upregulates	compound	0.85
TD139	inhibits	drug	0.70
31375685	is a novel druggable target for	paper	0.60
31375685	formed puncta in	paper	0.60
microglia	activates	cell_type	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.625	neuroscience	Lysosomal dysfunction and cathepsin leak
Aberrant Galectin-3 Expression on Stressed Synapses Creates	0.610	synaptic biology	What determines the selectivity of compl
Galectin-3 as Damage-Sensor Scaffold for Multimeric Cross-Se	0.455	neurodegeneration	Protein aggregation cross-seeding across