Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about enteric nervous system: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alpha-Synuclein Spread | mediates | process | 0.80 |
| Gut-to-Brain Alpha-Synuclein Spread | mediates | mechanism | 0.80 |
| Amyotrophic Lateral Sclerosis | involved_in | disease | 0.75 |
| alpha-synuclein burden | modulates | phenotype | 0.70 |
| alpha-synuclein | expressed_in | protein | 0.70 |
| substantia nigra | regulates | brain_region | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Microbiota-Gut-Brain Axis | interacts_with | pathway | 0.95 |
| Gut Microbiota | interacts_with | cell_type | 0.95 |
| Microbiota | interacts_with | process | 0.90 |
| MICROBIOTA | interacts_with | process | 0.80 |
| SNCA | associated_with | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Enteric Nervous System Dysfunction as Self-Reinforcing Patho | 0.630 | neurodegeneration | Gut-Brain Axis in Parkinson's Disease: M |
| H7: Enteric Nervous System Alpha-Synuclein Propagation Block | 0.620 | neurodegeneration | How does engineered C. butyricum cross t |
| Enteric Nervous System Prion-Like Propagation Blockade | 0.480 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-24 | 6 hypotheses Top: 0.670
neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiation Mechanis | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Computational Modeling of Alpha-Synuclein Propagation in PD | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Alpha-Synuclein Seed Amplification Assay Validation | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation and Neuro | exploratory | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,070,000 |
| Antiviral Therapy Trial for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Alpha-Synuclein Staging and Spreading in DLB — Spatial Propagation Map | validation | Parkinson's Disease | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| Genetic Risk Modifiers in DLB Phenotype | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Tau Co-Pathology in DLB Clinical Heterogeneity | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symp [PMID:36965781] | ["Ishola IO", "Awogbindin IO", "Olubodun | Neurotoxicology | 2023 | 1 |
| Toll-like receptor expression in the blood and brain of patients and a mouse mod [PMID:25522431] | Drouin-Ouellet J, St-Amour I, Saint-Pier | The international journal of n | 2014 | 1 |
| Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeut [PMID:41465422] | Ahremenko E, Andreev A, Apushkin D, Kork | International journal of molec | 2025 | 0 |
| Co-exposure to polystyrene nanoplastics and glyphosate exacerbates NETs-mediated [PMID:40554107] | ["Zeng H", "Qi J", "Chen Q", "Zhang R", | Ecotoxicology and environmenta | 2025 | 0 |
| Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] | Wang W, Wang Y, Wang F, Xie G, Liu S, Li | Phytomedicine : international | 2024 | 0 |
| The Body, the Brain, the Environment, and Parkinson's Disease. [PMID:38607765] | ["Dorsey E Ray", "De Miranda Briana R", | Journal of Parkinson's disease | 2024 | 0 |
| Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] | Wang W, Wang Y, Wang F, Xie G, Liu S, Li | Phytomedicine : international | 2024 | 0 |
| Limonin (LM) and its derivatives: Unveiling the neuroprotective and anti-inflamm [PMID:39117089] | ["Panda S", "Kesharwani A", "Singh M", " | Fitoterapia | 2024 | 0 |
| The role of the microbiota in glaucoma. [PMID:37866106] | Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa | Molecular aspects of medicine | 2023 | 0 |
| The role of the microbiota in glaucoma. [PMID:37866106] | Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa | Molecular aspects of medicine | 2023 | 0 |
| Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogen [PMID:36455790] | Claudino Dos Santos JC, Lima MPP, Brito | Ageing Res Rev | 2023 | 0 |
| Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut micr [PMID:35652241] | ["Liu S", "Kang W", "Mao X", "Ge L", "Du | Journal of pineal research | 2022 | 0 |
| Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoi [PMID:36311762] | ["Aziz S", "Almajhdi F", "Waqas M", "Ull | Frontiers in immunology | 2022 | 0 |
| Galectin-3, a rising star in modulating microglia activation under conditions of [PMID:35859075] | ["Garc\u00eda-Revilla J", "Boza-Serrano | Cell death & disease | 2022 | 0 |
| The microbiome-gut-brain axis in Parkinson disease - from basic research to the [PMID:35750883] | Tan AH, Lim SY, Lang AE | Nat Rev Neurol | 2022 | 0 |
| The role of gut dysbiosis in Parkinson's disease: mechanistic insights and thera [PMID:33856024] | Unknown | Brain : a journal of neurology | 2021 | 0 |
| The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocyt [PMID:31790685] | ["Wu S", "Zhao M", "Sun Y", "Xie M", "Le | Life sciences | 2020 | 0 |
| Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061] | Choi I, Zhang Y, Seegobin SP | Nat Commun | 2020 | 0 |
| Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation. [PMID:32087283] | Yang L, Zhou R, Tong Y, Chen P, Shen Y, | Neurobiology of disease | 2020 | 0 |
| Synucleinphagy: a microglial "community cleanup program" for neuroprotection. [PMID:32453651] | ["Choi I", "Seegobin S", "Liang D", "Yue | Autophagy | 2020 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.63 · 2026-04-24
closed · Rounds: 4 · Score: 0.82 · 2026-04-22
Hypotheses and analyses mentioning enteric nervous system in their description or question text
No additional research found