gene

adcy8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adcy8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

7Hypotheses

1Analyses

15Outgoing

3Incoming

3Experiments

1Debates

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🧬 Gene Info

Gene Symbol	ADCY8
Full Name	Adenylate Cyclase 8
Chromosome	8q24.22
Function	ADCY8 plays essential roles in neuronal physiology:
Molecular Weight	125 kDa
Exons	28
GeneCards	ADCY8
Human Protein Atlas	ADCY8
N-terminal extracellular domain	Contains glycosylation sites
Transmembrane region (M1-M6)	Forms the membrane-spanning core
Calmodulin-binding domain	Located in the C-terminal cytoplasmic region
Cerebral cortex	Layer-specific expression in pyramidal neurons
Cerebellum	Enriched in Purkinje cells
Associated Diseases	long_term_spatial_memory_formation, migratory distance
SciDEX Hypotheses	Hippocampal ADCY8 Upregulation for Alzheimer's Nav Circadian-Spatial Memory Coupling Therapy ADCY8-Mediated Synaptic Tagging for Spatial Memori (+4 more)
KG Connections	18 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADCY8 Gene

gene · 863 words

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Pathway Diagram

flowchart TD
    N0["ADCY8"]
    N1["AND"]
    N0 -->|"regulates"| N1
    N2["Ras"]
    N0 -->|"expressed in"| N2
    N3["App"]
    N0 -->|"expressed in"| N3
    N4["neurodegeneration"]
    N0 -->|"implicated in"| N4

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 protein
    class N3 protein

Outgoing (15)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY8	data_in	dataset_row	0.00
cAMP	produces	molecule	0.90
spatial_navigation	modulates	cognitive_function	0.90
migratory distance	associated_with	phenotype	0.85
long-term memory	involved_in	process	0.80
population-level migration differences	contributes_to	phenotype	0.79
hippocampus	regulates	brain_region	0.70
long_term_spatial_memory_formation	causes	phenotype	0.70
epigenetic_programming	modulates	mechanism	0.70
navigation_disorders	protective_against	disease	0.70
synaptic_plasticity	modulates	process	0.70
adenylyl_cyclase_activity	enhances	process	0.70
circadian_rhythms	couples_with	process	0.70
Ras	expressed_in	protein	0.60
App	expressed_in	protein	0.60

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY8	data_in	dataset_row	0.00
long-term memory	drives	process	0.75
Falco peregrinus	expressed_in	cell_type	0.70

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ADCY8-PKA-CREB Spatial Memory Enhancement	0.455	memory and navigation	How does ADCY8 mechanistically regulate
ADCY8-cAMP Memory Consolidation Enhancer	0.455	memory and navigation	How does ADCY8 mechanistically regulate
Hippocampal ADCY8 Upregulation for Alzheimer's Navigation De	0.455	memory and navigation	How does ADCY8 mechanistically regulate
ADCY8-Mediated Synaptic Tagging for Spatial Memories	0.455	memory and navigation	How does ADCY8 mechanistically regulate
Circadian-Spatial Memory Coupling Therapy	0.455	memory and navigation	How does ADCY8 mechanistically regulate

Epigenetic ADCY8 Memory Programming	0.455	memory and navigation	How does ADCY8 mechanistically regulate
Magnetic Field Sensing-Memory Interface Therapy	0.455	memory and navigation	How does ADCY8 mechanistically regulate

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does ADCY8 mechanistically regulate long-term memory formation in migratory

memory and navigation | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Score	Model	Status	Est. Cost
Genome resequencing and GWAS for migratory distance in peregrine falco	exploratory	0.850	wild peregrine falcons (Falco	proposed	N/A
Genome resequencing and association with migratory distance	exploratory	0.850	wild peregrine falcon populati	proposed	N/A
ADCY8 regulatory mechanism investigation	exploratory	0.750	peregrine falcon populations	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study identifies ADCY8 as associated with migratory distance differences and

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning adcy8 in their description or question text

Epigenetic ADCY8 Memory Programming

Score: 0.455 · memory and navigation · 2026-04-27

The memory-based navigation differences associated with ADCY8 may involve epigenetic programming during critical develop

Magnetic Field Sensing-Memory Interface Therapy

Score: 0.455 · memory and navigation · 2026-04-27

ADCY8 may integrate magnetic field sensing with memory formation for navigation. Therapeutic stimulation combining magne