protein

WAVE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WAVE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

1Outgoing

3Incoming

0Experiments

0Debates

Summary

WAVE1 protein - Arp2/3 activation, actin polymerization, AD, ASD

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🔬 Protein Info

Gene Symbol	WAVE1
Aliases	WAVE1 protein
Function	WAVE1 (WASP family verprolin homologous protein 1) is a key regulator of actin cytoskeleton dynamics that activates the Arp2/3 complex to nucleate branched actin networks.
Molecular Weight	63.6 kDa
GeneCards	WAVE1
Human Protein Atlas	WAVE1
Associated Diseases	Parkinson
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

WAVE1 Protein

protein · 636 words

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Pathway Diagram

flowchart TD
    N0["WAVE1"]
    N1["Parkinson"]
    N0 -->|"associated with"| N1
    N2["HNRNPA1"]
    N2 -->|"regulates"| N0
    N3["SFPQ"]
    N3 -->|"co expressed with"| N0
    N4["SNCA"]
    N4 -->|"co expressed with"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 protein
    class N4 gene

Outgoing (1)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.60

Incoming (3)

Source	Relation	Type	Str
HNRNPA1	regulates	gene	0.50
SFPQ	co_expressed_with	protein	0.50
SNCA	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WAVE1 in their description or question text

No additional research found