concept

USP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

17Outgoing

5Incoming

0Experiments

0Debates

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💡 Concept Info

Name	USP4
Key Genes/Proteins	AND, AUTOPHAGY, Fus, LYSOSOME, RAB7A, Raf
Related Diseases	Periodontitis
Related Pathways	Autophagy, autophagy pathway, oxidative stress response, ubiquitin-proteasome

Pathway Diagram

graph TD
    USP4["USP4"]
    USP4 -->|"deubiquitinates"| RAB7A["RAB7A"]
    USP4 -.protects against.-> Periodontitis["Periodontitis"]
    USP4 -->|"promotes"| Autophagosome_Lysosome_Fusion["Autophagosome-Lysosome Fusion"]
    USP4 -->|"inhibits"| UBIQUITIN["UBIQUITIN"]
    USP4 -->|"inhibits"| Autophagy["Autophagy"]
    USP4 -->|"inhibits"| Macrophage["Macrophage"]
    USP4 -->|"inhibits"| AND["AND"]
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| USP4
    LYSOSOME["LYSOSOME"] -->|"inhibits"| USP4
    RAB7A -->|"inhibits"| USP4
    UBIQUITIN -->|"inhibits"| USP4

Outgoing (17)

Target	Relation	Type	Str
RAB7A	deubiquitinates	protein	0.85
Periodontitis	protects_against	disease	0.85
RAB7A	regulates	protein	0.80
RAB7A	depletion_impairs_ubiquitylation	protein	0.80
Raf	inhibits	protein	0.60
Fus	inhibits	protein	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
LYSOSOME	inhibits	gene	0.60
RAB7A	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
Macrophage	inhibits	cell_type	0.60
UBIQUITIN	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
AND	inhibits	gene	0.60
Macrophage	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
AUTOPHAGY	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
RAB7A	inhibits	gene	0.60
RAB7A	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity