Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Tau protein / microtubule-associated pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Noradrenergic-Tau Propagation Blockade | 0.711 | neurodegeneration | Sleep disruption as cause and consequenc |
| Selective Tau Kinase Inhibition in Vulnerable Neuronal Subty | 0.676 | neurodegeneration | Cell type vulnerability in Alzheimers Di |
| Locus Coeruleus-Hippocampal Circuit Protection | 0.668 | neuroscience | Circuit-level neural dynamics in neurode |
| Synaptic Vesicle Tau Capture Inhibition | 0.578 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
| HSP90-Tau Disaggregation Complex Enhancement | 0.575 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plasma ATN biomarkers across AD continuum in Chilean cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Chilean older adults (n=318) w | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Differential GWAS of schizophrenia vs PTSD | exploratory | schizophrenia, post-traumatic | 0.900 | 0.00 | human patients - European ance | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Creation and validation of 3xAD-ChAT-Cre mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | 3xAD-ChAT-Cre transgenic mice | proposed | N/A |
| Endothelial CD2AP knockdown effects on memory in male mice | validation | Alzheimer's disease | 0.900 | 0.00 | male mice | proposed | N/A |
| Amyloid plaque load analysis in triple-mutant mouse brains | exploratory | Alzheimer's disease | 0.880 | 0.00 | APP/PSEN1/GD3S-/- triple-trans | proposed | N/A |
| Reelin treatment rescue via ApoER2 in CD2AP mutant mice | validation | Alzheimer's disease | 0.870 | 0.00 | mice | proposed | N/A |
| GTEx brain tissue expression analysis of MAPT/CRHR1 locus | exploratory | schizophrenia, post-traumatic | 0.850 | 0.00 | human brain tissue samples fro | proposed | N/A |
| MRI Phenotyping Method Concordance in Serbian AD Cohort | clinical | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue in male CD2AP mice | validation | Alzheimer's disease | 0.850 | 0.00 | male mice | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue experiment | validation | Alzheimer's disease | 0.850 | 0.00 | mice | proposed | N/A |
| In vivo BBB transport of LPS-carrying bEVs | validation | Alzheimer's disease | 0.850 | 0.00 | mice | proposed | N/A |
| Neuroimmune modulation and Aβ clearance mechanisms | exploratory | Alzheimer's disease | 0.820 | 0.00 | Microglia and astrocytes | proposed | N/A |
| Microtubule domain analysis in adult axons | exploratory | 0.800 | 0.00 | adult rodent axons | proposed | N/A | |
| Tau depletion effects on microtubule domains in adult axons | exploratory | 0.800 | 0.00 | adult rodent neurons | proposed | N/A | |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| 16S rRNA sequencing of gut microbiome in PH-PS treated mice | exploratory | Alzheimer's disease | 0.800 | 0.00 | 5×FAD transgenic mice | proposed | N/A |
| Competing endogenous RNA (ceRNA) network construction | exploratory | Alzheimer's disease | 0.750 | 0.00 | computational network analysis | proposed | N/A |
| s:** - Compare tau strain spreading in EXT1/EXT2 conditional knockout | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $260,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641] | Zhang X, Wei M, Fan J, Yan W, Zha X, Son | Autophagy | 2021 | 1 |
| Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 po [PMID:31227597] | Snyder AG, Hubbard NW, Messmer MN, Kofma | Sci Immunol | 2019 | 1 |
| Effect of etching with potassium hydrogen difluoride and ammonium hydrogen diflu [PMID:31068549] | Akazawa N, Koizumi H, Nogawa H, Kodaira | Dent Mater J | 2019 | 1 |
| Synapse formation in the brain can be enhanced by co-administering three specifi [PMID:29031899] | Wurtman RJ | Eur J Pharmacol | 2017 | 1 |
| Engineered AAVs for efficient noninvasive gene delivery to the central and perip [PMID:28671695] | Chan KY, Jang MJ, Yoo BB, Greenbaum A, R | Nat Neurosci | 2017 | 1 |
| The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. [PMID:25937488] | Jernigan TL, Brown TT, Hagler DJ Jr, Aks | Neuroimage | 2016 | 1 |
| Regulation of Lipid Biology-Associated Gene Expression in Granulosa Cells in Hyp [PMID:41605187] | ["Berkel C"] | Lipids | 2026 | 0 |
| Gigantol: a principal bioactive constituent of Dendrobium species-multi-target m [PMID:40939944] | Shi S, Zhu C, Xu J, Sui Q, Zhu S, Zhang | Journal of ethnopharmacology | 2026 | 0 |
| Meta-GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammali [PMID:41504393] | ["Lin Q", "Cai X", "Zhong Z", "Li T", "C | Advanced science (Weinheim, Ba | 2026 | 0 |
| Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks. [PMID:41714746] | ["Petersen Kellen K", "Mil\u00e0-Alom\u0 | Nature medicine | 2026 | 0 |
| Necl1 deficiency induces noradrenergic dysfunction and depressive-like states in [PMID:41308882] | ["Song J", "Wang L", "Suo J", "Ran K", " | Journal of affective disorders | 2026 | 0 |
| A minimally invasive dried blood spot biomarker test for the detection of Alzhei [PMID:41491101] | Huber H, Montoliu-Gaya L, Brum WS, Vávra | Nat Med | 2026 | 0 |
| Biomimetic cancer cell membrane-coated liposomal nanocarriers loaded with silibi [PMID:41585438] | Yao J, Sun Q, Zhang X, Yang D, Wu H et a | Mater Today Bio | 2026 | 0 |
| Experimental and translational models of Alzheimer's disease: From neurodegenera [PMID:41619411] | Khan N, De S, Boddu S, Pravala N | J Prev Alzheimers Dis | 2026 | 0 |
| TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-media [PMID:41642658] | Konishi S, Enkhbayar K, Liu S, Miyashita | J Clin Invest | 2026 | 0 |
| Exploring synergistic therapeutic potential of Erlotinib and artemisinin in non- [PMID:41672289] | Suleman F, Khan T, Alshehade SA, Ali M, | Clin Chim Acta | 2026 | 0 |
| Spontaneous tauopathy with parkinsonism in an aged cynomolgus macaque. [PMID:41695270] | Takahashi M, Taniguchi D, Funayama M, Ci | Front Aging Neurosci | 2026 | 0 |
| Differential genome-wide association analysis of schizophrenia and post-traumati [PMID:41767305] | Cheng ZS | Front Genet | 2026 | 0 |
| Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's dis [PMID:41804841] | Kim JP, Song M, Cho M, Lee H, Jung SH et | Alzheimers Dement | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning Tau protein / microtubule-associated pathway in their description or question text
No additional research found