Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRYPTOPHAN METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TRYPTOPHAN METABOLISM |
| Key Genes/Proteins | APP |
| Related Diseases | ALZHEIMER'S DISEASE, CANCER, GLAUCOMA |
graph TD
TRYPTOPHAN_METABOLISM[TRYPTOPHAN METABOLISM]
TRYPTOPHAN_METABOLISM -->|mediates| Microbiota_Gut_Brain_Axis[Microbiota-Gut-Brain Axis]
TRYPTOPHAN_METABOLISM -->|modulates| INFLAMMATION[INFLAMMATION]
TRYPTOPHAN_METABOLISM -->|regulates| NEUROINFLAMMATION[NEUROINFLAMMATION]
TRYPTOPHAN_METABOLISM -->|involved_in| Glaucoma[Glaucoma]
APP[APP] -->|inhibits| TRYPTOPHAN_METABOLISM
KYNURENINE_PATHWAY[KYNURENINE PATHWAY] -->|implicated in| TRYPTOPHAN_METABOLISM
GLAUCOMA[GLAUCOMA] -->|inhibits| TRYPTOPHAN_METABOLISM
MACROPHAGES[MACROPHAGES] -->|activates| TRYPTOPHAN_METABOLISM
CANCER[CANCER] -->|activates| TRYPTOPHAN_METABOLISM
ALZHEIMER_S_DISEASE[ALZHEIMER'S DISEASE] -->|inhibits| TRYPTOPHAN_METABOLISM
NEUROINFLAMMATION -->|inhibits| TRYPTOPHAN_METABOLISM| Target | Relation | Type | Str |
|---|---|---|---|
| Microbiota-Gut-Brain Axis | mediates | pathway | 0.90 |
| colorectal cancer | associated_with | disease | 0.90 |
| INFLAMMATION | modulates | process | 0.85 |
| NEUROINFLAMMATION | regulates | process | 0.85 |
| Microbiota-Gut-Brain Axis | involved_in | pathway | 0.85 |
| Glaucoma | involved_in | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Glaucoma | associated_with | disease | 0.80 |
| APP | inhibits | gene | 0.35 |
| KYNURENINE PATHWAY | implicated_in | process | 0.35 |
| GLAUCOMA | inhibits | disease | 0.35 |
| MACROPHAGES | activates | cell_type | 0.35 |
| CANCER | activates | disease | 0.35 |
| ALZHEIMER'S DISEASE | inhibits | disease | 0.35 |
| NEUROINFLAMMATION | inhibits | process | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Restoring Neuroprotective Tryptophan Metabolism via Targeted | 0.612 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microcephaly-associated protein WDR62 supports purine metabolism by interacting [PMID:41787126] | Morris MJ, Yeap YY, Edwards JR, Chen C, | EMBO J | 2026 | 0 |
| Nonvital Pulp Therapy in Primary Teeth Using Mineral Trioxide Aggregate Obturati [PMID:41928850] | Makiguchi T, Terauchi Y, Wong K, Bogen G | Case Rep Dent | 2026 | 0 |
| Gut Microbiota and Dopamine: Producers, Consumers, Enzymatic Mechanisms, and In [PMID:41595985] | Albani G, Chellamuthu VR, Morlacchi L, Z | Bioengineering (Basel, Switzer | 2025 | 0 |
| Chemically induced reprogramming to reverse cellular aging. [PMID:37437248] | Yang JH, Petty CA, Dixon-McDougall T, Lo | Aging | 2023 | 0 |
| Mechanisms of peripheral levodopa resistance in Parkinson's disease. [PMID:35546556] | Beckers M, Bloem BR, Verbeek MM | NPJ Parkinson's disease | 2022 | 0 |
| Melatonin metabolism, signaling and possible roles in plants. [PMID:32645752] | Back K | The Plant journal : for cell a | 2021 | 0 |
| FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update [PMID:33562601] | ["Pignataro P", "Dicarlo M", "Zerlotin R | International journal of molec | 2021 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] | Liu J, Xie J | International journal of envir | 2020 | 0 |
| Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] | Karas M, Marinsek N, Goldhahn J, Foschin | Digital biomarkers | 2020 | 0 |
| The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels [PMID:30027497] | ["Afshar S", "Shahidi S", "Rohani A", "K | Psychopharmacology | 2018 | 0 |
| Melatonin and Expression of Tryptophan Decarboxylase Gene (TDC) in Herbaceous Pe [PMID:29757219] | Zhao D, Wang R, Liu D, Wu Y, Sun J, Tao | Molecules (Basel, Switzerland) | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TRYPTOPHAN METABOLISM in their description or question text
No additional research found