protein

TNFPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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Summary

Tumor necrosis factor alpha (TNF-α) is a potent pro-inflammatory cytokine that plays a central role in immune regulation, inflammation, and cell survival.

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🔬 Protein Info

Gene Symbol	TNFPROTEIN
Full Name	Tumor Necrosis Factor Alpha
Chromosome	6p21.33
Protein Family	TNF Superfamily
Function	is a potent pro-inflammatory cytokine that plays a central role in immune regulation, inflammation, and cell survival.
Molecular Weight	25.6 kDa (monomer), 52.4 kDa (trimer)
Amino Acids	233 amino acids
UniProt ID	P01375
NCBI Gene ID	7124
GeneCards	TNFPROTEIN
Human Protein Atlas	TNFPROTEIN
Associated Diseases	A1_astrocytes, AD, Age-related macular degeneration, Aging, Alopecia Areata, Als
Known Drugs/Compounds	ACBA, Adalimumab, Andrographis paniculata, anti-TNF-α monoclonal antibody, BAICALEIN, berberine
Interactions	A2M, ABCA1, ABCB1, ABCG1, ABCG2, ACE
SciDEX Hypotheses	Temporal Window Specificity
KG Connections	5616 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFPROTEIN — AlphaFold P01375 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TNF Alpha Protein

protein · 1063 words

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Pathway Diagram

graph TD
    TNFPROTEIN["TNFPROTEIN"]
    neurodegeneration["neurodegeneration"]
    TNFPROTEIN -->|"implicated_in"| neurodegeneration
    style TNFPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNFPROTEIN in their description or question text

No additional research found