protein 1,063 words KG: TNFPROTEIN
Contents

TNF Alpha Protein

🔬 Protein Info
Gene SymbolTNFPROTEIN
Full NameTumor Necrosis Factor Alpha
Chromosome6p21.33
Protein FamilyTNF Superfamily
Functionis a potent pro-inflammatory cytokine that plays a central role in immune regulation, inflammation, and cell survival.
Molecular Weight25.6 kDa (monomer), 52.4 kDa (trimer)
Amino Acids233 amino acids
UniProt IDP01375
NCBI Gene ID7124
GeneCardsTNFPROTEIN
Human Protein AtlasTNFPROTEIN
Associated DiseasesA1_astrocytes, AD, Age-related macular degeneration, Aging, Alopecia Areata, Als
Known Drugs/CompoundsACBA, Adalimumab, Andrographis paniculata, anti-TNF-α monoclonal antibody, BAICALEIN, berberine
InteractionsA2M, ABCA1, ABCB1, ABCG1, ABCG2, ACE
SciDEX HypothesesTemporal Window Specificity
KG Connections5616 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (11)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · completed
Systemic immune profiling and peripheral immune contribution
neurodegeneration · completed
Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Why do systemic anti-inflammatory drugs fail in AD despite c
clinical neurology · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (30)

Electroacupuncture ST37 treatment for DSS-induced colitis in
validation · proposed · Score: 0.95
Acteoside treatment in LPS-induced SALI mouse model
validation · proposed · Score: 0.90
Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90
In vitro PANoptosis protection by LPT1 in hepatocytes
exploratory · proposed · Score: 0.80
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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