Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Post-Stroke Depression | involved_in | disease | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Epigenetic Memory Erasure via TET2 Activation | 0.741 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| TET2-Mediated Demethylation Rejuvenation Therapy | 0.706 | neurodegeneration | Epigenetic clocks and biological aging i |
| H1: TET-Mediated 5-Hydroxymethylcytosine Loss Drives Neurona | 0.670 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| Temporal TET2-Mediated Hydroxymethylation Cycling | 0.657 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Neuronal TET1 Upregulation Reactivates Immediate-Early Genes | 0.640 | neurodegeneration | epigenetic reprogramming aging neurons |
| TET Enzyme-Mediated 5hmC Restoration as Neuronal Rejuvenatio | 0.620 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| Targeted DNA Demethylation at the Klotho Locus via dCas9-TET | 0.510 | neurodegeneration | epigenetic reprogramming aging neurons |
| TET Enzyme Enhancement to Prevent Aberrant DNA Methylation | 0.350 | neurodegeneration | Comparative epigenetic signatures across |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Tet2 modulation in Aβ42-injured mouse hippocampal neurons | exploratory | Alzheimer's disease | 0.900 | 0.00 | primary mouse hippocampal neur | proposed | N/A |
| AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study | validation | Alzheimer's disease | 0.900 | 0.00 | young APPswe/PSEN1 double-tran | proposed | N/A |
| Tet2 expression analysis in aged 2×Tg-AD mouse brains | exploratory | Alzheimer's disease | 0.850 | 0.00 | APPswe/PSEN1 double-transgenic | proposed | N/A |
| Proposed experiment from debate on Epigenetic clocks and biological ag | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | completed | $450,000 |
| CRISPR Gene Correction Approaches for CBS/PSP | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| DNA Damage Repair Deficiency Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | completed | $7,500,000 |
| Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar | validation | Neurodegeneration | 0.400 | 0.50 | human | completed | $3,000,000 |
| Epigenetic Dysregulation Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo | validation | Parkinson's Disease | 0.400 | 0.50 | human | completed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507] | Koh Y, Tengesdal IW, Jaiswal S | Annu Rev Pathol | 2026 | 1 |
| TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094] | Jain N, Zhao Z, Feucht J, Koche R, Iyer | Nature | 2023 | 1 |
| Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826] | Singh I, Singh A | Curr Oncol Rep | 2023 | 1 |
| The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059] | Cong B, Zhang Q, Cao X | Protein Cell | 2021 | 1 |
| SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264] | Turner JS, Kim W, Kalaidina E, Goss CW, | Res Sq | 2020 | 1 |
| Reply to Rosen: Temperature-growth relationship is robust. [PMID:31375623] | Diffenbaugh NS, Burke M | Proc Natl Acad Sci U S A | 2019 | 1 |
| Cryo-electron microscopy structures of human oligosaccharyltransferase complexes [PMID:31831667] | Ramírez AS, Kowal J, Locher KP | Science | 2019 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with [PMID:28068668] | Britschgi A, Duss S, Kim S, Couto JP, Br | Nature | 2017 | 1 |
| CD161 defines a transcriptional and functional phenotype across distinct human T [PMID:25437561] | Fergusson JR, Smith KE, Fleming VM, Rajo | Cell Rep | 2014 | 1 |
| Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740] | Hannum G, Guinney J, Zhao L, Zhang L, Hu | Mol Cell | 2013 | 1 |
| Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890] | Lister R, Mukamel EA, Nery JR, Urich M, | Science | 2013 | 1 |
| TET1 deficiency amplifies macrophage inflammatory signaling associated with Croh [PMID:41896302] | ["Perez R", "Paul R", "Kumar P", "Tutkun | Inflammation research : offici | 2026 | 0 |
| Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389] | Liu K, Hong Y, Gao Q, Huang J, Liu L, Li | Cellular and molecular life sc | 2026 | 0 |
| Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms. [PMID:41899316] | ["Sinnadurai S", "Honigberg M", "Meijers | Journal of clinical medicine | 2026 | 0 |
| Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects. [PMID:41926089] | Park CS, Ryu G, Ahn HJ, Sun C, Lee SP, K | JAMA oncology | 2026 | 0 |
| IRG1-itaconate axis in immunometabolism: mechanistic roles and therapeutic poten [PMID:41743716] | Liu Y, Zhang P, Kong W, Li J, Yang H, Ba | Frontiers in immunology | 2026 | 0 |
| DNA Methylation in the Ovary and Uterus of Mammalian Animal Models: Implications [PMID:41751612] | Serej O, Kowalik MK, Rekawiecki R | Genes | 2026 | 0 |
| Chimeric antigen receptor T-cell therapies related to immune effector cell-assoc [PMID:41914034] | Zhang Y, Yang J, Xin H, Ai K, Yang M, Li | Chinese medical journal | 2026 | 0 |
| Promoter demethylation and protein O-GlcNAcylation-mediated enhancement of fatty [PMID:41360204] | Lin ZH, Chou PI, Chang JW, Lin ZC, Sun Y | J Nutr Biochem | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TET in their description or question text
Score: 0.620 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The ten-eleven translocation (TET) enzyme family, comprising TET1, TET2, and TET3
Score: 0.510 · neurodegeneration · 2026-04-22
## Mechanistic Overview Targeted DNA Demethylation at the Klotho Locus via dCas9-TET1 Rescues Neuroprotective Klotho Exp
Score: 0.350 · neurodegeneration · 2026-04-25
TET Enzyme Enhancement to Prevent Aberrant DNA Methylation