protein

TAC1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAC1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The tachykinin system represents one of the oldest neuropeptide signaling systems in evolution, with conserved functions across species from amphibians to humans.

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🔬 Protein Info

Gene Symbol	TAC1PROTEIN
Chromosome	7q21
Function	The tachykinin system represents one of the oldest neuropeptide signaling systems in evolution, with conserved functions across species from amphibians to humans.
Primary Expression	distinct neuronal populations within the basal ganglia, cortex, hippocampus, and brainstem, where they modulate dopaminergic signaling, GABAergic tran
Molecular Weight	17 kDa
Amino Acids	11 aa
GeneCards	TAC1PROTEIN
Human Protein Atlas	TAC1PROTEIN
Preprotachykinin-A (PPT-A)	Generates Substance P (SP, 11 amino acids), Neurokinin A (NKA, 10 amino acids), neuropeptide K (NPK, 36 amino acids), and neuropeptide γ (NPγ, 21 amino acids)
Preprotachykinin-B (PPT-B)	Generates Neurokinin B (NKB, 10 amino acids), encoded by the separate TAC3 gene
Associated Diseases	neurodegeneration
Interactions	TRPM8, WNT3A
KG Connections	26 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TAC1 (Tachykinin Precursor 1) Protein

protein · 1709 words

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Pathway Diagram

graph TD
    TAC1PROTEIN["TAC1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TAC1PROTEIN -->|"implicated_in"| neurodegeneration
    style TAC1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning TAC1PROTEIN in their description or question text

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