Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Splicing: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Stress-induced TDP-43 Nuclear Condensation | inhibits | process | 0.93 |
| 33618777 | is critical prerequisite for | paper | 0.90 |
| TARDBP | regulates | protein | 0.90 |
| RNA-BINDING PROTEINS | regulates | protein | 0.90 |
| TDP-43 | regulates | protein | 0.90 |
| Protein Arginine Methyltransferases | regulates | protein | 0.90 |
| U2AF1 | regulates | gene | 0.85 |
| PRMT1 | regulates | entity | 0.85 |
| PRMT5 | regulates | entity | 0.85 |
| TDP-43 | regulates | protein | 0.80 |
| CHMP7 | inhibits | protein | 0.80 |
| BIN1 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| MATR3 Nuclear Body Disruption Impairs RNA Processing Hubs an | 0.818 | ALS | - |
| Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulat | 0.620 | neurodegeneration | Gap 006 analysis (archived stub) |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning Splicing in their description or question text
No additional research found