| Gene Symbol | SURF4 |
| Full Name | SURF4 Homolog |
| Chromosome | 8q11.23 |
| Protein Type | ER Cargo Receptor |
| Function | is a highly conserved gene encoding an endoplasmic reticulum (ER) cargo receptor protein that plays a critical role in the early secretory pathway. |
| Amino Acids | 440 aa |
| NCBI Gene ID | 6836 |
| OMIM | 605332 |
| GeneCards | SURF4 |
| Human Protein Atlas | SURF4 |
| Cargo Recognition | SURF4 binds to properly folded secretory proteins and specific transmembrane cargo molecules, serving as a physical link between cargo and the COPII coat 3. |
| Export Site Formation | SURF4 localizes to ER exit sites (ERES) where it helps nucleate the formation of COPII vesicles. Its cytoplasmic tail directly engages Sec24 through the DxE motif, recruiting the coat machinery 6. |
| Associated Diseases | Cardiovascular |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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