Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:STS | data_in | dataset_row | 0.00 |
| oxidative stress response | participates_in | pathway | 0.80 |
| apoptosis pathway | participates_in | pathway | 0.80 |
| MS | associated_with | disease | 0.80 |
| Autoimmune | associated_with | disease | 0.65 |
| neurons | expressed_in | cell_type | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:STS | data_in | dataset_row | 0.00 |
| lithium | targets | drug | 0.80 |
| DNA | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in dia [PMID:41054305] | Xiong Y, Li R, Chen X, Peng C, Zeng Q, Z | Mol Ther | 2026 | 1 |
| Chemerin-CMKLR1 differentially mediated OGD/R-induced mitochondrial dysfunction, [PMID:41151300] | Long PY, Tang Z, Cai N, Yan ZQ, Gao X, W | Biomed Pharmacother | 2025 | 1 |
| The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/I [PMID:34330814] | Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B, | Sci Immunol | 2021 | 1 |
| Microglial Aβ receptors in Alzheimer's disease. [PMID:25149075] | Yu Y, Ye RD | Cell Mol Neurobiol | 2015 | 1 |
| Molecular Signaling and Biased Agonism of the CHEMR23 Receptor: Implications for [PMID:41486998] | ["Neprelyuk O", "Romanenko I", "Irza O", | Current protein & peptide scie | 2026 | 0 |
| Receptor-Mediated Shuttling of a D-Amino Acid Peptide Achieves High Nanomolar Cy [PMID:41422545] | ["List M", "Beck-Sickinger A"] | Journal of the American Chemic | 2026 | 0 |
| Activation of stimulator of interferon genes (STING) and inhibition of vascular [PMID:41380972] | Wang Y, Hou Y, Han J, Zhang Z, Cheng Y e | J Biol Chem | 2026 | 0 |
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053] | Ye R, Wang S, Hu Y, Pan Y, Zheng W et al | Science | 2026 | 0 |
| The cGAS-STING signaling pathway: A central regulator and novel therapeutic targ [PMID:41765111] | Jiang H, Ji Y, Shang T, Qi L, Li Z et al | Biochem Pharmacol | 2026 | 0 |
| cGAS-STING and PANoptosis: Interplay, Underlying Mechanisms, and Therapeutic Tar [PMID:42016387] | Wang Y, Chen J, Feng W, Li N, Zhang X et | Drug Des Devel Ther | 2026 | 0 |
| Follicle-dependent differential localization of adipokines in the letrozole-indu [PMID:41857436] | ["Dutta A", "Gurusubramanian G", "Roy V" | Histochemistry and cell biolog | 2026 | 0 |
| Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Mid [PMID:41538650] | ["Zhu Z", "Du F", "Liu Y", "Yang J", "Ge | Advanced science (Weinheim, Ba | 2026 | 0 |
| Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary a [PMID:36600187] | ["Sanges S", "Rice L", "Tu L", "Valenzi | Annals of the rheumatic diseas | 2023 | 0 |
| The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Depos [PMID:36012305] | Chen Y, Liu Z, Gong P, Zhang H, Chen Y, | International journal of molec | 2022 | 0 |
| Chemerin partly mediates tumor-inhibitory effect of all-trans retinoic acid via [PMID:31063220] | Song Y, Yin W, Dan Y, Sheng J, Zeng Y, H | Immunology | 2019 | 0 |
| Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in d [PMID:30784180] | ["Shang J", "Wang L", "Zhang Y", "Zhang | Journal of cellular and molecu | 2019 | 0 |
| Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri [PMID:27860453] | ["Huang J", "Burston J", "Li L", "Ashraf | Arthritis & rheumatology (Hobo | 2017 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STS in their description or question text
Score: 0.530 · neurodegeneration · 2026-04-25
Mislocalized tau impairs dendritic endosome-lysosome and autophagy flux, trapping tau species in the somatodendritic com
Score: 0.520 · neurodegeneration · 2026-04-22
## Mechanistic Overview Therapeutic Window Exists Through Activity-Dependent Regulation of Synaptic Vesicle Priming star
Score: 0.492 · neurodegeneration · 2026-04-22
## Mechanistic Overview YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1 Transcription in Perivascular Fibro
Score: 0.460 · neurodegeneration · 2026-04-25
Aβ initially perturbs tau localization, but persistence depends on BIN1-regulated membrane and endocytic trafficking tha
Score: 0.442 · neurodegeneration · 2026-04-22
## Mechanistic Overview RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upregulation in Perivascular Fibroblasts
Score: 0.430 · connectomics · 2026-04-25
GABAergic Hub Stabilization Through α5-Subunit Inverse Agonists