gene

SPTBN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPTBN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for SPTBN2 Gene

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🧬 Gene Info

Gene Symbol	SPTBN2
Protein Family	Spectrin family (β-spectrin)
Function	SPTBN2 encodes βIII-spectrin, a critical cytoskeletal protein that stabilizes the plasma membrane and organizes protein complexes in neurons.
Primary Expression	Primarily in neurons, especially cerebellar Purkinje cells
Molecular Weight	272 kDa
UniProt ID	O15020
Ensembl ID	ENSG00000173898
GeneCards	SPTBN2
Human Protein Atlas	SPTBN2
Molecular weight	~272 kDa
Cellular localization	Cytoskeleton, plasma membrane
Cytoskeletal stability	Forms meshwork under plasma membrane
Protein anchoring	Links membrane proteins to actin cytoskeleton
Organelle trafficking	Facilitates vesicular transport
Synaptic function	Maintains postsynaptic density architecture
Associated Diseases	neurodegeneration
KG Connections	5 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SPTBN2 — AlphaFold O15020 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SPTBN2 Gene

gene · 644 words

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Pathway Diagram

graph TD
    SPTBN2["SPTBN2"]
    Epilepsy{"Epilepsy"}
    SPTBN2 -->|"expressed in"| Epilepsy
    Als{"Als"}
    SPTBN2 -->|"expressed in"| Als
    Autism{"Autism"}
    SPTBN2 -->|"expressed in"| Autism
    GENES["GENES"]
    SPTBN2 -->|"associated with"| GENES
    SPTBN4["SPTBN4"]
    SPTBN2 -->|"associated with"| SPTBN4
    neurodegeneration["neurodegeneration"]
    SPTBN2 -->|"implicated in"| neurodegeneration
    style SPTBN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Epilepsy	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
GENES	associated_with	gene	0.60
SPTBN4	associated_with	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPTBN2 in their description or question text

No additional research found