| Gene Symbol | SPTBN2 |
| Protein Family | Spectrin family (β-spectrin) |
| Function | SPTBN2 encodes βIII-spectrin, a critical cytoskeletal protein that stabilizes the plasma membrane and organizes protein complexes in neurons. |
| Primary Expression | Primarily in neurons, especially cerebellar Purkinje cells |
| Molecular Weight | 272 kDa |
| UniProt ID | O15020 |
| Ensembl ID | ENSG00000173898 |
| GeneCards | SPTBN2 |
| Human Protein Atlas | SPTBN2 |
| Molecular weight | ~272 kDa |
| Cellular localization | Cytoskeleton, plasma membrane |
| Cytoskeletal stability | Forms meshwork under plasma membrane |
| Protein anchoring | Links membrane proteins to actin cytoskeleton |
| Organelle trafficking | Facilitates vesicular transport |
| Synaptic function | Maintains postsynaptic density architecture |
| Associated Diseases | neurodegeneration |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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