gene

SEPTIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEPTIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for SEPTIN2 Gene

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🧬 Gene Info

Gene Symbol	Septin 2
Aliases	SEPTIN2
Chromosome	2q37.3
Protein Family	Septin GTPases
Function	is a founding member of the septin family of GTP-binding proteins that play essential roles in cytoskeletal organization, membrane dynamics, and cellular signaling.
Molecular Weight	41.5 kDa
Amino Acids	361 aa
UniProt ID	Q15020
NCBI Gene ID	4735
OMIM	601680
GTPase activity	SEPTIN2 binds GTP and undergoes conformational changes upon nucleotide hydrolysis, enabling it to act as a molecular switch
Scaffold formation	Septin filaments serve as platforms for protein kinase localization and signaling complex assembly
Membrane organization	Septins associate with plasma membrane microdomains and organelle membranes
Cytoskeletal interaction	SEPTIN2 bridges actin filaments and microtubules, influencing cytoskeletal dynamics
Autophagy regulation	Septins participate in autophagosome formation and cargo selective autophagy[@tth2016]
Associated Diseases	neurodegeneration
Interactions	INFLAMMATION, RAC1
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SEPTIN2 — AlphaFold Q15020 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SEPTIN2 Gene

gene · 827 words

→

SEPTIN2 Protein

protein · 665 words

→

Pathway Diagram

graph TD
    SEPTIN2["SEPTIN2"]
    Cardiovascular{"Cardiovascular"}
    SEPTIN2 -->|"activates"| Cardiovascular
    Inflammation{"Inflammation"}
    SEPTIN2 -->|"activates"| Inflammation
    RAC1["RAC1"]
    SEPTIN2 -->|"activates"| RAC1
    INFLAMMATION["INFLAMMATION"]
    SEPTIN2 -->|"activates"| INFLAMMATION
    neurodegeneration["neurodegeneration"]
    SEPTIN2 -->|"implicated in"| neurodegeneration
    style SEPTIN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Cardiovascular	activates	disease	0.65
Inflammation	activates	disease	0.65
INFLAMMATION	activates	gene	0.60
RAC1	activates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SEPTIN2 in their description or question text

No additional research found