Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RYR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RYR3 |
| Full Name | Ryanodine Receptor 3 |
| Aliases | Page for RYR3 |
| Chromosome | 15q13.3 |
| Protein Family | Ryanodine receptor family |
| Protein Type | Receptor |
| Function | RYR3 is the third ryanodine receptor isoform with widespread but lower expression than RYR1/RYR2. |
| Primary Expression | numerous tissues including skeletal muscle, brain, heart, and other organs |
| Molecular Weight | 560 kDa |
| Amino Acids | 870 aa |
| UniProt ID | Q15413 |
| NCBI Gene ID | 6263 |
| Ensembl ID | ENSG00000198853 |
| GeneCards | RYR3 |
| Human Protein Atlas | RYR3 |
| Associated Diseases | Cardiac |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RYR3["RYR3"]
Als{"Als"}
RYR3 -->|"expressed in"| Als
Cardiac{"Cardiac"}
RYR3 -->|"associated with"| Cardiac
neurodegeneration["neurodegeneration"]
RYR3 -->|"implicated in"| neurodegeneration
RYR2["RYR2"]
RYR2 -->|"associated with"| RYR3
CAT["CAT"]
CAT -->|"expressed in"| RYR3
RYR1["RYR1"]
RYR1 -->|"associated with"| RYR3
style RYR3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RYR3 in their description or question text
No additional research found