Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RYR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RYR1 encodes the ryanodine receptor 1 calcium release channel, essential for muscle contraction and neuronal calcium signaling. Dysfunction implicated in Alzheimer's disease, Parkinson's disease, and neuromuscular disorders.
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| Gene Symbol | RYR1 |
| Full Name | Ryanodine Receptor 1 |
| Protein Family | Ryanodine receptor family |
| Protein Type | Channel |
| Function | RYR1 is a large calcium release channel on the sarcoplasmic reticulum in skeletal muscle. |
| Primary Expression | various brain regions including the hippocampus and cerebellum, where it contributes to synaptic plasticity, dendritic s |
| Molecular Weight | 564 kDa |
| Amino Acids | 038 aa |
| UniProt ID | P21817 |
| GeneCards | RYR1 |
| Human Protein Atlas | RYR1 |
| Associated Diseases | Cardiac |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RYR1["RYR1"]
Als{"Als"}
RYR1 -->|"expressed in"| Als
Cardiac{"Cardiac"}
RYR1 -->|"associated with"| Cardiac
RYR3["RYR3"]
RYR1 -->|"associated with"| RYR3
neurodegeneration["neurodegeneration"]
RYR1 -->|"implicated in"| neurodegeneration
RYR2["RYR2"]
RYR2 -->|"associated with"| RYR1
CAT["CAT"]
CAT -->|"regulates"| RYR1
style RYR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RYR1 in their description or question text
No additional research found