Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RETREG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RETREG3 |
| Full Name | Reticulophagy Regulator 3 |
| Chromosome | 5q31.1 |
| Function | is a critical endoplasmic reticulum (ER)-resident protein that functions as an autophagy receptor mediating reticulophagy—the selective degradation of ER components through the autophagy-lysosome p... |
| Subcellular Localization | . This region shows less conservation compared to RETREG1, suggesting possible functional divergence between the two par |
| Molecular Weight | 48 kDa |
| Amino Acids | 449 aa |
| Exons | 7 |
| UniProt ID | Q8N6I6 |
| NCBI Gene ID | 642473 |
| Ensembl ID | ENSG00000175318 |
| GeneCards | RETREG3 |
| Human Protein Atlas | RETREG3 |
| Sumoylation | Functional studies suggest SUMO modification of RETREG3 under stress conditions, potentially regulating its oligomerization state [5]. |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease |
| Interactions | AUTOPHAGY, LC3 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RETREG3["RETREG3"]
AUTOPHAGY["AUTOPHAGY"]
RETREG3 -->|"interacts with"| AUTOPHAGY
BMPR1A["BMPR1A"]
RETREG3 -->|"regulates"| BMPR1A
ATG5["ATG5"]
RETREG3 -->|"regulates"| ATG5
LC3["LC3"]
RETREG3 -->|"interacts with"| LC3
Autophagy(["Autophagy"])
RETREG3 -->|"interacts with"| Autophagy
neurodegeneration["neurodegeneration"]
RETREG3 -->|"implicated in"| neurodegeneration
style RETREG3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RETREG3 in their description or question text
No additional research found