entity

PVALB/SST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PVALB/SST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

1Hypotheses

1Analyses

2Outgoing

4Incoming

0Experiments

4Debates

No AI portrait yet

Outgoing (2)

Target	Relation	Type	Str
neuroscience	associated_with	disease	0.50
VIP	co_associated_with	gene	0.40

Incoming (4)

Source	Relation	Type	Str
CAMK2A	co_associated_with	gene	0.40
CHAT	co_associated_with	gene	0.40
GRIN2B	co_associated_with	gene	0.40
MAPT	co_associated_with	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Differential Interneuron Optogenetic Restoration Therapy	0.599	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 68 hypotheses Top: 1.000

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y, Z	Journal of affective disorders	2026
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026

Debates (4)

Multi-agent debates referencing this entity

Hypothesis debate: Closed-loop optogenetic targeting PV interneurons to restore

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Closed-loop transcranial focused ultrasound targeting EC-II S

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Closed-loop transcranial focused ultrasound with 40Hz gamma e

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning PVALB/SST in their description or question text

No additional research found