gene

PPP3CA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP3CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

3Outgoing

1Incoming

0Experiments

0Debates

Summary

Gene page for PPP3CA (Calcineurin)

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🧬 Gene Info

Gene Symbol	PPP3CA
Aliases	Calcineurin
Chromosome	4p16.3
Protein Type	Phosphatase
Function	is a unique calcium/calmodulin-dependent phosphatase that plays critical roles in neuronal signal transduction, synaptic plasticity, gene transcription, and immune cell activation[@klee1979].
Primary Expression	a tissue-specific manner:
Molecular Weight	59 kDa
Amino Acids	521 aa
Exons	14
GeneCards	PPP3CA
Human Protein Atlas	PPP3CA
PPP3CA (α isoform)	Predominantly expressed in brain tissue, particularly in the hippocampus and cerebral cortex
PPP3CB (β isoform)	Enriched in immune cells and testis
PPP3CC (γ isoform)	Testis-specific expression
Catalytic subunit (CNA)	Contains the phosphatase domain, calcineurin B (CNB) binding domain, and auto-inhibitory domain
Associated Diseases	Axon Repulsion, neurodegeneration
Interactions	NLRP3
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PPP3CA(["PPP3CA"])
    Growth_Cone_Turning("Growth Cone Turning")
    Axon_Repulsion("Axon Repulsion")
    Calcium["Calcium"]
    CAMK2A["CAMK2A"]
    cAMP["cAMP"]
    neurodegeneration["neurodegeneration"]

    PPP3CA -->|"mediates"| Growth_Cone_Turning
    PPP3CA -->|"associated with"| Axon_Repulsion
    Calcium -->|"activates"| PPP3CA
    CAMK2A -->|"interacts with"| PPP3CA
    cAMP -.->|"inhibits"| PPP3CA
    PPP3CA -->|"implicated in"| neurodegeneration

    style PPP3CA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
pyroptosis	participates_in	pathway	0.60
neuroinflammation	activates	disease	0.60
microglia	expressed_in	cell_type	0.55

Incoming (1)

Source	Relation	Type	Str
NLRP3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP3CA in their description or question text

No additional research found