| Gene Symbol | PPP3CA |
| Aliases | Calcineurin |
| Chromosome | 4p16.3 |
| Protein Type | Phosphatase |
| Function | is a unique calcium/calmodulin-dependent phosphatase that plays critical roles in neuronal signal transduction, synaptic plasticity, gene transcription, and immune cell activation[@klee1979]. |
| Primary Expression | a tissue-specific manner: |
| Molecular Weight | 59 kDa |
| Amino Acids | 521 aa |
| Exons | 14 |
| GeneCards | PPP3CA |
| Human Protein Atlas | PPP3CA |
| PPP3CA (α isoform) | Predominantly expressed in brain tissue, particularly in the hippocampus and cerebral cortex |
| PPP3CB (β isoform) | Enriched in immune cells and testis |
| PPP3CC (γ isoform) | Testis-specific expression |
| Catalytic subunit (CNA) | Contains the phosphatase domain, calcineurin B (CNB) binding domain, and auto-inhibitory domain |
| Associated Diseases | Axon Repulsion, neurodegeneration |
| Interactions | NLRP3 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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