| Gene Symbol | P16234 |
| Protein Type | Serine/Threonine Phosphatase |
| Function | is a calcium/calmodulin-dependent serine/threonine phosphatase that plays a critical role in cellular signaling, synaptic plasticity, and immune response. |
| Molecular Weight | 64 kDa |
| GeneCards | P16234 |
| Human Protein Atlas | P16234 |
| Catalytic A subunit (PPP3CA) | A 59-64 kDa protein containing the phosphatase active site, a calmodulin-binding domain, and an auto-inhibitory domain that regulates enzyme activity |
| Regulatory B subunit (PPP3R1) | An 19 kDa calcium-binding protein belonging to the calmodulin superfamily that confers calcium sensitivity to the complex |
| T-cell activation | NFAT-regulated genes control interleukin-2 production and T-cell proliferation |
| Synaptic plasticity | NFAT signaling modulates long-term potentiation and memory formation |
| Cardiac development | NFAT coordinates cardiac morphogenesis in response to mechanical stress |
| Neuronal differentiation | NFAT influences neurogenesis and neuronal subtype specification |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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