gene

PPM1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPM1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

9Outgoing

6Incoming

0Experiments

0Debates

Summary

PPM1B (Protein Phosphatase Mg2+/Mn2+ Dependent 1B) is a serine/threonine phosphatase involved in stress kinase regulation, synaptic plasticity, and neurodegenerative disease mechanisms.

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🧬 Gene Info

Gene Symbol	PPM1B
Full Name	Protein Phosphatase Mg2+/Mn2+ Dependent 1B
Chromosome	2p21
Protein Type	Serine/Threonine Phosphatase
Function	p38 MAPK Pathway: Dephosphorylates and inactivates p38 MAPK, reducing stress-induced apoptosis
Subcellular Localization	and protein interactions
Amino Acids	471 aa
Pathways	MAPK
UniProt ID	[Q06180](https://www.uniprot.org/uniprot/Q06180)
Ensembl ID	ENSG00000172548
OMIM	608002
GeneCards	PPM1B
Human Protein Atlas	PPM1B
Metal Ion Dependence	Requires Mg2+ or Mn2+ for phosphohydrolase activity
Substrate Specificity	Prefers serine and threonine residues in specific contexts
Associated Diseases	ALS
Interactions	AMPK, AND, AUTOPHAGY, MLKL
KG Connections	15 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPM1B Gene

gene · 1438 words

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Pathway Diagram

graph TD
    PPM1B["PPM1B"]
    Als{"Als"}
    PPM1B -->|"activates"| Als
    ALS{"ALS"}
    PPM1B -->|"activates"| ALS
    Carcinoma{"Carcinoma"}
    PPM1B -->|"activates"| Carcinoma
    Autophagy(["Autophagy"])
    PPM1B -->|"activates"| Autophagy
    AUTOPHAGY["AUTOPHAGY"]
    PPM1B -->|"activates"| AUTOPHAGY
    Hepatocyte["Hepatocyte"]
    PPM1B -->|"activates"| Hepatocyte
    AMPK["AMPK"]
    AMPK -->|"activates"| PPM1B
    MLKL["MLKL"]
    MLKL -->|"activates"| PPM1B
    AUTOPHAGY -->|"activates"| PPM1B
    AND["AND"]
    AND -->|"activates"| PPM1B
    PPM1B -->|"activates"| AMPK
    neurodegeneration["neurodegeneration"]
    PPM1B -->|"implicated_in"| neurodegeneration

Outgoing (9)

Target	Relation	Type	Str
ALS	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	activates	disease	0.65
Autophagy	activates	pathway	0.60
necroptosis	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
AUTOPHAGY	activates	gene	0.60
Hepatocyte	activates	cell_type	0.60
AMPK	activates	protein	0.50

Incoming (6)

Source	Relation	Type	Str
MLKL	activates	gene	0.60
AMPK	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	activates	gene	0.60
MLKL	co_expressed_with	gene	0.50
AMPK	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPM1B in their description or question text

No additional research found