gene

MTRR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTRR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

6Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for MTRR Gene

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🧬 Gene Info

Gene Symbol	MTRR
Full Name	5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase
Chromosome	5p15.31
Protein Type	Enzyme
Function	is a gene encoding the enzyme methionine synthase reductase, which plays a critical role in folate and homocysteine metabolism.
Molecular Weight	80 kDa
Amino Acids	726 aa
UniProt ID	Q9UQ50
NCBI Gene ID	4552
Ensembl ID	ENSG00000124275
OMIM	602568
GeneCards	MTRR
Human Protein Atlas	MTRR
Associated Diseases	neurodegeneration
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MTRR — AlphaFold Q9UQ50 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MTRR Gene

gene · 1027 words

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Pathway Diagram

graph TD
    MTRR["MTRR"]
    Als{"Als"}
    MTRR -->|"expressed in"| Als
    Autism{"Autism"}
    MTRR -->|"expressed in"| Autism
    ANTIOXIDANT_GENES["ANTIOXIDANT GENES"]
    MTRR -->|"expressed in"| ANTIOXIDANT_GENES
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    MTRR -->|"expressed in"| OXIDATIVE_STRESS
    NRF2["NRF2"]
    MTRR -->|"expressed in"| NRF2
    Oxidative_Stress(["Oxidative Stress"])
    MTRR -->|"expressed in"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    MTRR -->|"implicated in"| neurodegeneration
    NFE2L2["NFE2L2"]
    NFE2L2 -->|"expressed in"| MTRR
    style MTRR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
ANTIOXIDANT GENES	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
NRF2	expressed_in	gene	0.60

Incoming (1)

Source	Relation	Type	Str
NFE2L2	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MTRR in their description or question text

No additional research found