gene

MAPK11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for MAPK11

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🧬 Gene Info

Gene Symbol	MAPK11
Full Name	Mitogen-Activated Protein Kinase 11
Aliases	Mitogen-activated protein kinase 11 (p38β)
Chromosome	22q12.1
Function	is a major signaling cascade activated by cellular stress and pro-inflammatory cytokines.
Molecular Weight	41 kDa
Pathways	MAPK, MAPK pathway
UniProt ID	[Q16643](https://www.uniprot.org/uniprot/Q16643)
GeneCards	MAPK11
Human Protein Atlas	MAPK11
Environmental stress	UV radiation, oxidative stress, hypoxia
Inflammatory cytokines	IL-1β, TNF-α, IL-6
Growth factors	Some growth factor signaling pathways
Pathogen-associated molecules	LPS through TLR signaling
Microglial activation	Controls pro-inflammatory cytokine production
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Neuroinflammation, Stroke
Known Drugs/Compounds	Losmapimod
KG Connections	1 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MAPK11

gene · 820 words

→

MAPK11 Protein (p38β)

protein · 822 words

→

Pathway Diagram

graph TD
    A["MAPK11
(p38beta MAPK)"]
    B["Cellular Stress
Stimuli"]
    C["MKK3/MKK6
Kinases"]
    D["ATF2
Transcription Factor"]
    E["CREB
Transcription Factor"]
    F["Pro-inflammatory
Cytokines"]
    G["Neuronal
Apoptosis"]
    H["Synaptic
Dysfunction"]
    I["Neurodegeneration"]
    J["Alzheimer's
Disease"]
    K["Parkinson's
Disease"]
    L["Losmapimod
Inhibitor"]
    M["Oxidative
Stress"]
    N["Tau
Phosphorylation"]

    B -->|"activates"| C
    C -->|"phosphorylates"| A
    M -->|"activates"| A
    A -->|"phosphorylates"| D
    A -->|"phosphorylates"| E
    A -->|"promotes"| F
    A -->|"induces"| G
    A -->|"impairs"| H
    A -->|"phosphorylates"| N
    F -->|"contributes to"| I
    G -->|"leads to"| I
    H -->|"contributes to"| I
    N -->|"promotes"| I
    I -->|"manifests as"| J
    I -->|"manifests as"| K
    L -->|"inhibits"| A

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    classDef therapeutic fill:#1a3a2a,stroke:#81c784,stroke-width:2px

    class A central
    class F,G,H,I,M,N pathological
    class C,D,E regulatory
    class J,K disease
    class L therapeutic
    class B pathological

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
Losmapimod	inhibits	drug	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK11 in their description or question text

No additional research found