Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lipid Metabolism Dysregulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | causes | disease | 0.90 |
| Proximal Tubular Epithelial Cells | associated_with | cell_type | 0.90 |
| blood-brain barrier integrity | associated_with | phenotype | 0.85 |
| neuronal function | associated_with | phenotype | 0.85 |
| Alzheimer'S Disease | associated_with | disease | 0.80 |
| Parkinson'S Disease | associated_with | disease | 0.80 |
| systemic inflammation | associated_with | process | 0.78 |
| microglial senescence | causes | phenotype | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| apoe4 | causes | disease | 0.90 |
| NFKB1 | drives | gene | 0.80 |
| astrocytes | involved_in | cell_type | 0.75 |
| TREM2 deficiency | causes | process | 0.70 |
| lactylation | regulates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2 Deficiency Drives Microglial Senescence via Lipid Meta | 0.836 | neurodegeneration | What molecular mechanisms drive microgli |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.836
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells [PMID:41674808] | Acharya A, Ambikan AT, Neogi U, Lamberty | Res Sq | 2026 | 0 |
| Siah2 is a lipid-mediated metabolic sensor in adipose tissue macrophage. [PMID:41690475] | Dang TN, Ghosh B, Panta PR, Taylor JM, K | J Lipid Res | 2026 | 0 |
| Apolipoprotein E dysfunction in Alzheimer's disease: a study on miRNA regulation [PMID:39744521] | ["Wijesinghe Printha", "Li Hao Ran", "Ai | Frontiers in aging neuroscienc | 2024 | 0 |
| Trem2-deficiency aggravates and accelerates age-related myelin degeneration. [PMID:39300502] | ["McCray Tyler J", "Bedford Logan M", "B | Acta neuropathologica communic | 2024 | 0 |
| CD300f immune receptor contributes to healthy aging by regulating inflammaging, [PMID:37864797] | Evans F, Alí-Ruiz D, Rego N, Negro-Demon | Cell reports | 2023 | 0 |
| Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk f [PMID:36411364] | Holstege H, Hulsman M, Charbonnier C | Nat Genet | 2022 | 0 |
| The role of innate immune genes in Alzheimer's disease. [PMID:33560670] | Griciuc A, Tanzi RE | Curr Opin Neurol | 2021 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.46 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.79 · 2026-04-22
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Hypotheses and analyses mentioning Lipid Metabolism Dysregulation in their description or question text
No additional research found