concept

LATE-ONSET ALZHEIMER'S DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LATE-ONSET ALZHEIMER'S DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

2Analyses

1Outgoing

43Incoming

0Experiments

3Debates

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💡 Concept Info

Name	LATE-ONSET ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    LATE_ONSET_ALZHEIMER_S_DISEASE["LATE-ONSET ALZHEIMER'S DISEASE"]
    LATE_ONSET_ALZHEIMER_S_DISEASE -->|"causes"| Molecular_Interaction_Structur["Molecular Interaction Structure"]
    APOE4["APOE4"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    BIN1["BIN1"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    APOE["APOE"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    TREM2["TREM2"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE
    Decreased_Lipidated_ApoE_LDLR_["Decreased Lipidated ApoE-LDLR Interaction"] -.protects against.-> LATE_ONSET_ALZHEIMER_S_DISEASE
    R47H["R47H"] -->|"risk_factor_for"| LATE_ONSET_ALZHEIMER_S_DISEASE

Outgoing (1)

Target	Relation	Type	Str
Molecular Interaction Structure	causes	mechanism	0.83

Incoming (43)

Source	Relation	Type	Str
APOE-ε4	associated_with	gene	1.00
APOE4	risk_factor_for	gene	0.98
BIN1	risk_factor_for	gene	0.95
TREM2	risk_factor_for	gene	0.95
APOE	risk_factor_for	gene	0.95
TYROBP	associated_with	gene	0.95
APOE	risk_factor_for	gene	0.95
Astrocytic Bioenergetic Failure	causes	mechanism	0.95
BIN1	risk_factor_for	gene	0.95
APOE4	associated_with	protein	0.95
APOE	risk_factor_for	gene	0.95
INPP5D	risk_factor_for	gene	0.93
Decreased Lipidated ApoE-LDLR Interaction	protects_against	mechanism	0.92
Immune and Microglia Module	associated_with	pathway	0.92
Neuroinflammation	contributes_to	process	0.92
Decreased Lipidated Apoe-Ldlr Interactions	protects_against	mechanism	0.90
TREM2 R47H	risk_factor_for	gene	0.90
33139712	is the strongest genetic risk factor associated with	paper	0.90
APOE4	risk_factor_for	gene	0.90
TREM2	risk_factor_for	gene	0.90
35453035	is the strongest predictor for	paper	0.90
30820047	is a risk locus for	paper	0.90
30820047	is a risk factor for	paper	0.90
21460841	is associated with	paper	0.90
TREM2	risk_factor_for	gene	0.90
30820047	are new risk loci for	paper	0.90
APOE ε4	associated_with	gene	0.90
38824138	determines risk of developing	paper	0.90
R47H	risk_factor_for	biomarker	0.90
24162737	identified for	paper	0.90
38824138	determine risk of developing	paper	0.90
Gene-Regulatory Networks	associated_with	pathway	0.88
LRP1	associated_with	gene	0.85
UNC5C	associated_with	gene	0.85
Inflammatory Pathway	involved_in	pathway	0.85
COMPLEMENT GENES	risk_factor_for	gene	0.85
Microglial Pathway	involved_in	pathway	0.80
TREM2	therapeutic_target_for	protein	0.70
genetic risk loci	associated_with	gene	0.70
30820047	is genetically correlated with	paper	0.60
CR1	therapeutic_target	gene	0.60
INPP5D	biomarker_for	gene	0.60
30514930	support biological coherence of	paper	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation

closed · Rounds: 4 · Score: 0.59 · 2026-04-27

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

While TREM2 was identified as critical for microglial senescence, the debate lac

closed · Rounds: 4 · Score: 0.73 · 2026-04-15

Related Research

Hypotheses and analyses mentioning LATE-ONSET ALZHEIMER'S DISEASE in their description or question text

No additional research found