concept

LINC00491

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LINC00491: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

17Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LINC00491
Key Genes/Proteins	AKT, ANXA1, PI3K, PURA, Purα
Related Diseases	cancer, Distant Metastasis, Nasopharyngeal Carcinoma, Nasopharyngeal Carcinoma Metastasis, Neoplastic Proliferation
Related Pathways	PI3K-AKT-mTOR signaling

Pathway Diagram

graph TD
    LINC00491[LINC00491]
    LINC00491 -->|binds| PURA[PURA]
    LINC00491 -->|promotes| Nasopharyngeal_Carcinoma[Nasopharyngeal Carcinoma]
    LINC00491 -->|binds| Pur_[Purα]
    LINC00491 -->|promotes| Nasopharyngeal_Carcinoma_Metas[Nasopharyngeal Carcinoma Metastasis]
    LINC00491 -->|risk_factor_for| patient_survival[patient survival]
    LINC00491 -->|upregulates| ANXA1[ANXA1]
    LINC00491 -->|promotes| Distant_Metastasis[Distant Metastasis]
    LINC00491 -->|implicated in| cancer[cancer]
    LINC00491 -->|activates| PI3K[PI3K]
    ANXA1 -->|activates| LINC00491
    AKT[AKT] -->|activates| LINC00491
    benchmark_ot_ad_answer_key_LIN[benchmark_ot_ad_answer_key:LINC00491] -->|data_in| LINC00491

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:LINC00491	data_in	dataset_row	0.00
Purα	binds	protein	0.95
Nasopharyngeal Carcinoma Metastasis	promotes	phenotype	0.95
Nasopharyngeal Carcinoma	promotes	disease	0.95
PURA	binds	protein	0.95
patient survival	risk_factor_for	phenotype	0.92
ANXA1	upregulates	gene	0.90
PURA nuclear to cytoplasmic translocation	associated_with	process	0.90
Neoplastic Proliferation	associated_with	phenotype	0.90
Distant Metastasis	promotes	phenotype	0.90
cell proliferation	associated_with	process	0.88
Nasopharyngeal Carcinoma	biomarker_for	disease	0.85
cancer	implicated_in	disease	0.60
PI3K	activates	gene	0.60
cancer	activates	disease	0.60
RNA	associated_with	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60

Incoming (4)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:LINC00491	data_in	dataset_row	0.00
ANXA1	activates	gene	0.60
AKT	activates	gene	0.60
ANXA1	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LINC00491 in their description or question text

No additional research found