Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KNL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KNL1 |
| Protein Type | Scaffold Protein |
| Function | is a fundamental kinetochore scaffold protein that links microtubules to centromeric chromatin and activates the spindle assembly checkpoint[@cheeseman2006]. |
| Primary Expression | proliferating cells: - High expression: Bone marrow, testis, embryonic tissues - Cell cycle-regulated: Peak in G2/M phase[@obrien2015] - Low in non-di |
| GeneCards | KNL1 |
| Human Protein Atlas | KNL1 |
| Microtubule attachment | KNL1 recruits the NDC80 and MIS12 complexes to form a functional kinetochore[@deluca2006] |
| Spindle checkpoint activation | BUB1 and BUBR1 phosphorylate KNL1 to generate checkpoint signals[@london2012] |
| Chromatin binding | Direct interaction with CENP-A nucleosomes at centromeres[@nishino2013] |
| Spindly recruitment | Recruits the dynein/dynactin complex for checkpoint silencing[@barisic2014] |
| Multiple cancers | KNL1 overexpression in aggressive tumors[@singh2014] |
| Chromosomal instability | KNL1 dysfunction leads to aneuploidy[@holland2014] |
| Therapeutic target | Potential for anti-mitotic therapy[@bakhoum2009] |
| Alzheimer's disease | Kinetochore dysfunction contributes to neuronal aneuploidy[@yang2001] |
| Aging | Age-related decline in kinetochore function[@baker2014] |
| Associated Diseases | Als, Cancer, Carcinoma |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["KNL1"]
N1["Als"]
N0 -->|"associated with"| N1
N2["Cancer"]
N0 -->|"associated with"| N2
N3["Carcinoma"]
N0 -->|"associated with"| N3
N4["CANCER"]
N0 -->|"associated with"| N4
N5["HSPA8"]
N0 -->|"associated with"| N5
N6["RPS6KA1"]
N0 -->|"associated with"| N6
N7["TRIM37"]
N0 -->|"associated with"| N7
N8["NOS2"]
N0 -->|"associated with"| N8
N9["NFKB1"]
N9 -->|"associated with"| N0
N10["RAB7A"]
N10 -->|"associated with"| N0
N11["CTNNB1"]
N11 -->|"associated with"| N0
N12["neurodegeneration"]
N0 -->|"implicated in"| N12
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classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 gene
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class N11 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KNL1 in their description or question text
No additional research found