gene

KIF3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

7Outgoing

6Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of KIF3B in axonal transport, neuronal development, ciliogenesis, and implications for Alzheimer's disease, Parkinson's disease, Joubert syndrome, and other neurodegenerative disorders.

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🧬 Gene Info

Gene Symbol	KIF3B
Full Name	Kinesin Family Member 3B
Chromosome	20q11.21
Function	KIF3B (Kinesin Family Member 3B) is the beta subunit of the heterotrimeric KIF3 motor complex, which also includes KIF3A and KAP3
Amino Acids	721 aa
Gene Type	Protein coding
UniProt ID	P49404
NCBI Gene ID	9377
Ensembl ID	ENSG00000101955
OMIM	604530
GeneCards	KIF3B
Human Protein Atlas	KIF3B
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KIF3B — AlphaFold P49404 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KIF3B — Kinesin Family Member 3B

gene · 2177 words

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Pathway Diagram

graph TD
    KIF3B["KIF3B"]
    Als{"Als"}
    KIF3B -->|"expressed in"| Als
    Ms{"Ms"}
    KIF3B -->|"inhibits"| Ms
    Neurodegeneration{"Neurodegeneration"}
    KIF3B -->|"expressed in"| Neurodegeneration
    APOPTOSIS["APOPTOSIS"]
    KIF3B -->|"expressed in"| APOPTOSIS
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    KIF3B -->|"expressed in"| OXIDATIVE_STRESS
    Apoptosis(["Apoptosis"])
    KIF3B -->|"expressed in"| Apoptosis
    Oxidative_Stress(["Oxidative Stress"])
    KIF3B -->|"expressed in"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    KIF3B -->|"implicated in"| neurodegeneration
    ICAM1["ICAM1"]
    ICAM1 -->|"expressed in"| KIF3B
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"expressed in"| KIF3B
    BAG1["BAG1"]
    BAG1 -->|"expressed in"| KIF3B
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| KIF3B
    SOD1["SOD1"]
    SOD1 -->|"expressed in"| KIF3B
    style KIF3B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Ms	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
APOPTOSIS	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
genes-kif3b	linked_to	wiki	1.00
NEURODEGENERATION	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ICAM1	expressed_in	gene	0.60
BAG1	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KIF3B in their description or question text

No additional research found