gene

KCND3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCND3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for KCND3 Gene

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🧬 Gene Info

Gene Symbol	KCND3
Chromosome	1p13.2
Protein Type	Channel
Function	The Kv4.3 channel (encoded by KCND3) is a voltage-gated potassium channel that mediates transient outward current (Ito) in neurons and cardiac myocytes.
Primary Expression	the hippocampus, cortex, and cerebellum, where it regulates neuronal excitability, back-propagation of action potentials, and
Amino Acids	636 aa
Exons	16
Ensembl ID	ENSG00000100285
GeneCards	KCND3
Human Protein Atlas	KCND3
S1-S4 domains	Voltage-sensing domain that detects membrane depolarization
S5-S6 domains	The pore region responsible for K+ ion selectivity and conductance
N-terminal T1 domain	Tetramerization domain for subunit assembly
C-terminal regulatory domain	Contains binding sites for auxiliary subunits and post-translational modifications
Cerebellum	Purkinje cells and granule cells - critical for motor coordination
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCND3 Gene

gene · 948 words

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Pathway Diagram

flowchart TD
    N0["KCND3"]
    N1["KCNE3"]
    N1 -->|"binds"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
KCNE3	binds	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCND3 in their description or question text

No additional research found