gene

IL35

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL35: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

9Outgoing

2Incoming

0Experiments

0Debates

Summary

Gene profile: IL35 - immunomodulatory cytokine composed of IL12A and IL27RB subunits, involved in regulatory T cell function, immunosuppression, and neuroinflammation in Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	IL35
Full Name	Interleukin 35
Aliases	Gene profile: IL35
Chromosome	5q33.1
Function	modulatory cytokine composed of IL12A and IL27RB subunits; regulatory T cell function
Pathways	gp130/STAT3/ferroptosis
UniProt ID	Q8IWU6
NCBI Gene ID	359948
GeneCards	IL35
Human Protein Atlas	IL35
IL12A (p35)	Shared with IL-12 and IL-35
IL27RB (EBI3)	Shared with IL-27
Associated Diseases	autoimmune diseases, cancer
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL35 — AlphaFold Q8IWU6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL35 — Interleukin 35

gene · 910 words

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Pathway Diagram

graph TD
    IL35["IL35"]
    HBV_related_HCC{"HBV-related HCC"}
    IL35 -->|"modulates"| HBV_related_HCC
    Th17_cells["Th17 cells"]
    IL35 -->|"inhibits"| Th17_cells
    IL6["IL6"]
    IL35 -->|"regulates"| IL6
    STAT3["STAT3"]
    IL35 -->|"regulates"| STAT3
    NETs["NETs"]
    IL35 -->|"inhibits"| NETs
    Th17_Treg_balance["Th17/Treg balance"]
    IL35 -->|"regulates"| Th17_Treg_balance
    gp130_STAT3_ferroptosis(["gp130/STAT3/ferroptosis"])
    IL35 -->|"regulates"| gp130_STAT3_ferroptosis
    autoimmune_diseases{"autoimmune diseases"}
    IL35 -->|"associated with"| autoimmune_diseases
    cancer{"cancer"}
    IL35 -->|"associated with"| cancer
    neurodegeneration["neurodegeneration"]
    IL35 -->|"implicated in"| neurodegeneration
    IL12["IL12"]
    IL12 -->|"component of"| IL35
    EBI3["EBI3"]
    EBI3 -->|"component of"| IL35
    style IL35 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
HBV-related HCC	modulates	disease	0.90
gp130/STAT3/ferroptosis	regulates	pathway	0.80
Th17/Treg balance	regulates	biological_process	0.80
Th17 cells	inhibits	cell_type	0.80
IL6	regulates	protein	0.80
STAT3	regulates	protein	0.80
NETs	inhibits	biological_process	0.80
cancer	associated_with	disease	0.70
autoimmune diseases	associated_with	disease	0.70

Incoming (2)

Source	Relation	Type	Str
EBI3	component_of	protein	0.90
IL12	component_of	protein	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL35 in their description or question text

No additional research found