protein

HTR1DPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR1DPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Htr1D Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HTR1DPROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the trigeminal ganglion, cranial vasculature, and specific brain regions, making it a crucial target for migraine therapy and neurological research
Subcellular Localization	** \| Plasma membrane \|
Molecular Weight	41 kDa
GeneCards	HTR1DPROTEIN
Human Protein Atlas	HTR1DPROTEIN
Presynaptic autoreceptor	Located on serotonergic nerve terminals to inhibit further serotonin release
Postsynaptic receptor	Modulates neuronal excitability in target regions
Cranial vasculature	Mediates serotonin-induced vasoconstriction
Platelets	Modulates platelet aggregation
Enteric nervous system	GI motility regulation
Mechanism	Agonist activation causes cranial vasoconstriction
Triptans	Sumatriptan, zolmitriptan, rizatriptan are 5-HT1D/5-HT1B agonists
Associated Diseases	neurodegeneration
Interactions	C-FOS, DEPRESSION, Rb
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

htr1d Protein

protein · 935 words

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Pathway Diagram

graph TD
    HTR1DPROTEIN["HTR1DPROTEIN"]
    neurodegeneration["neurodegeneration"]
    HTR1DPROTEIN -->|"implicated_in"| neurodegeneration
    style HTR1DPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTR1DPROTEIN in their description or question text

No additional research found