| Gene Symbol | HTR1DPROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the trigeminal ganglion, cranial vasculature, and specific brain regions, making it a crucial target for migraine therapy and neurological research |
| Subcellular Localization | ** | Plasma membrane | |
| Molecular Weight | 41 kDa |
| GeneCards | HTR1DPROTEIN |
| Human Protein Atlas | HTR1DPROTEIN |
| Presynaptic autoreceptor | Located on serotonergic nerve terminals to inhibit further serotonin release |
| Postsynaptic receptor | Modulates neuronal excitability in target regions |
| Cranial vasculature | Mediates serotonin-induced vasoconstriction |
| Platelets | Modulates platelet aggregation |
| Enteric nervous system | GI motility regulation |
| Mechanism | Agonist activation causes cranial vasoconstriction |
| Triptans | Sumatriptan, zolmitriptan, rizatriptan are 5-HT1D/5-HT1B agonists |
| Associated Diseases | neurodegeneration |
| Interactions | C-FOS, DEPRESSION, Rb |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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