protein

HSPA4PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA4PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Hsp110 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HSPA4PROTEIN
Full Name	Hsp110 / Hsp70-4
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Ubiquitous, high in brain, heart, testis
Molecular Weight	94 kDa
UniProt ID	P34932
GeneCards	HSPA4PROTEIN
Human Protein Atlas	HSPA4PROTEIN
ATP-Dependent Cycling	N-terminal ATPase domain regulates substrate binding
Hsp70/Hsp40 Collaboration	Forms functional complexes with Hsp70 and Hsp40
Disaggregationase Activity	Can extract proteins from pre-formed aggregates
Co-chaperone Interactions	Binds J-domain proteins for substrate delivery
Nuclear Import/Export	Facilitates nuclear-cytoplasmic transport of proteins
Alzheimer's Disease	Hsp110 may aid in clearing Aβ and tau aggregates
Associated Diseases	neurodegeneration
Interactions	CDK1, EGFR, ERBB2, FOXO1, GENES, GNB4
KG Connections	76 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HSPA4PROTEIN — AlphaFold P34932 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hsp110 Protein

protein · 628 words

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Pathway Diagram

graph TD
    HSPA4PROTEIN["HSPA4PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HSPA4PROTEIN -->|"implicated_in"| neurodegeneration
    style HSPA4PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPA4PROTEIN in their description or question text

No additional research found