gene

HSP90B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP90B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

HSP90B1 — Heat Shock Protein 90 Beta Family Member 1

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	HSP90B1
Full Name	Heat Shock Protein 90 Beta Family Member 1
Chromosome	15q26.3
Function	GRP94 (encoded by HSP90B1) is a member of the heat shock protein 90 family, distinguished by its ER-resident localization and unique client protein repertoire
Molecular Weight	90 kDa
Pathways	Mapk
UniProt ID	P14625
NCBI Gene ID	27197
OMIM	611719
GeneCards	HSP90B1
Human Protein Atlas	HSP90B1
Protein Folding	HSP90B1 assists in the folding and assembly of numerous client proteins, particularly those destined for secretion or membrane insertion.
Quality Control	Misfolded proteins are retained in the ER and targeted for ER-associated degradation (ERAD) if folding cannot be achieved.
Calcium Binding	HSP90B1 acts as a major calcium-binding protein in the ER, regulating calcium homeostasis.
ER Stress Response	HSP90B1 is upregulated during ER stress and participates in the unfolded protein response (UPR).
Associated Diseases	neurodegeneration
Interactions	CDK1, EGFR, ERBB2, FOXO1, GENES, GNB4
KG Connections	36 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSP90B1 — Heat Shock Protein 90 Beta Family Member 1

gene · 1009 words

→

HSP90B1 Gene

gene · 1104 words

→

Pathway Diagram

graph TD
    HSP90B["HSP90B"]
    neurodegeneration["neurodegeneration"]
    HSP90B -->|"implicated_in"| neurodegeneration
    style HSP90B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSP90B in their description or question text

No additional research found