gene

HCN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

6Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for HCN3

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🧬 Gene Info

Gene Symbol	HCN3
Chromosome	1p22.2
Protein Type	Gene
Function	encodes a voltage-gated ion channel subunit that contributes to hyperpolarization-activated inward current (Ih).
GeneCards	HCN3
Human Protein Atlas	HCN3
Associated Diseases	neurodegeneration
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HCN3

gene · 850 words

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HCN3 Protein

protein · 809 words

→

Pathway Diagram

flowchart TD
    N0["HCN3"]
    N1["GABA"]
    N0 -->|"expressed in"| N1
    N2["AND"]
    N2 -->|"activates"| N0
    N3["HCN1"]
    N3 -->|"expressed in"| N0
    N4["Ventral Tegmental Area"]
    N0 -->|"expressed in"| N4
    N5["Neuron"]
    N0 -->|"expressed in"| N5
    N0 -->|"expressed in"| N3
    N6["NEURONS"]
    N0 -->|"expressed in"| N6
    N7["DOPAMINE"]
    N0 -->|"expressed in"| N7
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene

Outgoing (6)

Target	Relation	Type	Str
GABA	expressed_in	gene	0.60
Neuron	expressed_in	cell_type	0.55
Ventral Tegmental Area	expressed_in	brain_region	0.55
NEURONS	expressed_in	concept	0.50
DOPAMINE	expressed_in	concept	0.50
HCN1	expressed_in	gene	0.50

Incoming (4)

Source	Relation	Type	Str
HCN1	expressed_in	gene	0.60
EPILEPSY	associated_with	gene	0.60
HCN1	co_mentioned	gene	0.40
GABA	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HCN3 in their description or question text

No additional research found