gene

FRDA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRDA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

7Outgoing

1Incoming

0Experiments

0Debates

Summary

FXN Gene (Frataxin)

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🧬 Gene Info

Gene Symbol	FRDA
Function	encodes a small mitochondrial protein that plays a critical role in iron-sulfur cluster (Fe-S) biogenesis, mitochondrial energy production, and cellular iron homeostasis.
Molecular Weight	~14 kDa (precursor), ~8 kDa (mature)
Amino Acids	210 aa
Ensembl ID	ENSG00000165060
GeneCards	FRDA
Human Protein Atlas	FRDA
Precursor	~210 amino acids
Mature form	~130 amino acids after processing
Molecular weight	~14 kDa (precursor), ~8 kDa (mature)
N-terminal helix	Mitochondrial targeting sequence (cleaved)
α-helical domain	Forms the core structure
β-sheet domain	Contains the iron-binding surface
Iron-binding sites	Acidic residues on the protein surface
Ferroxidase activity	Can oxidize Fe²⁺ to Fe³⁺
Associated Diseases	ALS, Ataxia, neurodegeneration
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FXN Gene (Frataxin)

gene · 1162 words

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FRDA1 Gene - Frataxin (FXN)

gene · 1608 words

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Pathway Diagram

graph TD
    FRDA["FRDA"]
    Ataxia["Ataxia"]
    FXN["FXN"]
    AND["AND"]
    neurodegeneration["neurodegeneration"]

    FRDA -->|"causes"| Ataxia
    FRDA -->|"causes"| FXN
    FRDA -->|"contributes to"| AND
    FRDA -->|"implicated in"| neurodegeneration

    style FRDA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Ataxia fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style FXN fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style AND fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (7)

Target	Relation	Type	Str
neurodegeneration	associated_with	disease	0.70
Ataxia	causes	disease	0.65
neurons	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
AND	contributes_to	gene	0.60
FXN	causes	gene	0.60
ALS	associated_with	disease	0.60

Incoming (1)

Source	Relation	Type	Str
FXN	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FRDA in their description or question text

No additional research found